Occurrence of composite cardiac endpoints with change in resting heart rate among Chinese patients with coronary artery disease: Chinese cohort from the real-world BISO-CAD study
| العنوان: | Occurrence of composite cardiac endpoints with change in resting heart rate among Chinese patients with coronary artery disease: Chinese cohort from the real-world BISO-CAD study |
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| المؤلفون: | Tianrong Ma, Zhan Lv, Xinchun Yang, Ming Yang, Feng Cao, Yu Yang, Qiangsun Zheng, Ningfu Wang, Xuchen Zhou, Guosheng Fu, Dong Xu, Haiyan Xu, Junxia Li, Yong Yuan, Xiaoping Chen, Xue-Dong Gan, Yundai Chen, Wenxian Liu, Huiliang Liu, Shian Huang, Tianlun Yang, Shaowen Liu |
| المصدر: | Current Medical Research and Opinion. 34:1921-1926 |
| بيانات النشر: | Informa UK Limited, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, China, medicine.medical_specialty, CAD, Coronary Artery Disease, 030204 cardiovascular system & hematology, Risk Assessment, RESTING HEART RATE, Cohort Studies, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Heart Rate, Internal medicine, medicine, Bisoprolol, Humans, 030212 general & internal medicine, Acute Coronary Syndrome, Aged, business.industry, Incidence, General Medicine, Middle Aged, Prognosis, medicine.disease, Adrenergic beta-1 Receptor Antagonists, Coronary heart disease, Treatment Outcome, Cohort, Cardiology, Female, sense organs, business, medicine.drug |
| الوصف: | We evaluated change in resting heart rate (RHR) and its impact on prognosis in Chinese coronary artery disease (CAD) patients treated with bisoprolol, and also assessed drug safety and tolerability.This phase IV, single arm observational study was a sub-study of the BISO-CAD study conducted across 20 hospitals in China between October 2011 and July 2015 with follow-up at 6, 12 and 18 months after baseline. The primary endpoint was occurrence of composite cardiac events.A total of 663 CAD patients (baseline RHR 75.47 ± 6.62 bpm) were enrolled in the intent-to-treat (ITT) set, and 513 patients were included in the efficacy analysis (EA) set. In the ITT set, the risk and the number of composite cardiac events in patients with mean RHR 69-74 bpm were significantly higher than in the65 bpm group (ITT: estimate 1.03 ± 0.47, p = .029). The incidence of the composite cardiac endpoint was not affected by continuous mean RHR (p = .5070). RHR significantly decreased from baseline to 18 months, most obviously in the first 6 months (p .0001). Ejection fraction and fractional shortening significantly improved in both the ITT and EA sets. An average RHR of 69-74 bpm had a significant effect on admission to hospital for acute coronary syndrome in the ITT (estimate 1.10, HR 3.004, p = .0196) and EA (estimate 1.26, HR 3.526, p = .0132) groups. Seven (1.1%) patients reported drug related adverse events.Reduction in RHR with bisoprolol lowered the incidence of composite cardiac events along with an acceptable safety and tolerability profile. |
| تدمد: | 1473-4877 0300-7995 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e6d7aef6d3436f37333e84ea3c9920Test https://doi.org/10.1080/03007995.2018.1454895Test |
| رقم الانضمام: | edsair.doi.dedup.....92e6d7aef6d3436f37333e84ea3c9920 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14734877 03007995 |
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