دورية أكاديمية
Optic Neuritis in Multiple Sclerosis—A Review of Molecular Mechanisms Involved in the Degenerative Process
| العنوان: | Optic Neuritis in Multiple Sclerosis—A Review of Molecular Mechanisms Involved in the Degenerative Process |
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| المؤلفون: | Manuela Andreea Ciapă, Delia Lidia Șalaru, Cristian Stătescu, Radu Andy Sascău, Camelia Margareta Bogdănici |
| المصدر: | Current Issues in Molecular Biology, Vol 44, Iss 9, Pp 3959-3979 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | inflammation, demyelination, remyelination, axonal degeneration, molecular mechanisms, Biology (General), QH301-705.5 |
| الوصف: | Multiple sclerosis is a central nervous system inflammatory demyelinating disease with a wide range of clinical symptoms, ocular involvement being frequently marked by the presence of optic neuritis (ON). The emergence and progression of ON in multiple sclerosis is based on various pathophysiological mechanisms, disease progression being secondary to inflammation, demyelination, or axonal degeneration. Early identification of changes associated with axonal degeneration or further investigation of the molecular processes underlying remyelination are current concerns of researchers in the field in view of the associated therapeutic potential. This article aims to review and summarize the scientific literature related to the main molecular mechanisms involved in defining ON as well as to analyze existing data in the literature on remyelination strategies in ON and their impact on long-term prognosis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1467-3045 1467-3037 |
| العلاقة: | https://www.mdpi.com/1467-3045/44/9/272Test; https://doaj.org/toc/1467-3037Test; https://doaj.org/toc/1467-3045Test |
| DOI: | 10.3390/cimb44090272 |
| الوصول الحر: | https://doaj.org/article/82a6394c038949668a87b64c383a9531Test |
| رقم الانضمام: | edsdoj.82a6394c038949668a87b64c383a9531 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14673045 14673037 |
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| DOI: | 10.3390/cimb44090272 |