دورية أكاديمية
Patients with Infections of The Central Nervous System Have Lowered Gut Microbiota Alpha Diversity
| العنوان: | Patients with Infections of The Central Nervous System Have Lowered Gut Microbiota Alpha Diversity |
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| المؤلفون: | Marta Grochowska, Tomasz Laskus, Marcin Paciorek, Agnieszka Pollak, Urszula Lechowicz, Michał Makowiecki, Andrzej Horban, Marek Radkowski, Karol Perlejewski |
| المصدر: | Current Issues in Molecular Biology, Vol 44, Iss 7, Pp 2903-2914 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | neuroinfection, encephalitis, gut microbiome, 16S rRNA sequencing, Biology (General), QH301-705.5 |
| الوصف: | There are multiple lines of evidence for the existence of communication between the central nervous system (CNS), gut, and intestinal microbiome. Despite extensive analysis conducted on various neurological disorders, the gut microbiome was not yet analyzed in neuroinfections. In the current study, we analyzed the gut microbiome in 47 consecutive patients hospitalized with neuroinfection (26 patients had viral encephalitis/meningitis; 8 patients had bacterial meningitis) and in 20 matched for age and gender health controls. Using the QIIME pipeline, 16S rRNA sequencing and classification into operational taxonomic units (OTUs) were performed on the earliest stool sample available. Bacterial taxa such as Clostridium, Anaerostipes, Lachnobacterium, Lachnospira, and Roseburia were decreased in patients with neuroinfection when compared to controls. Alpha diversity metrics showed lower within-sample diversity in patients with neuroinfections, though there were no differences in beta diversity. Furthermore, there was no significant change by short-term (1–3 days) antibiotic treatment on the gut microbiota, although alpha diversity metrics, such as Chao1 and Shannon’s index, were close to being statistically significant. The cause of differences between patients with neuroinfections and controls is unclear and could be due to inflammation accompanying the disease; however, the effect of diet modification and/or hospitalization cannot be excluded. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1467-3045 1467-3037 |
| العلاقة: | https://www.mdpi.com/1467-3045/44/7/200Test; https://doaj.org/toc/1467-3037Test; https://doaj.org/toc/1467-3045Test |
| DOI: | 10.3390/cimb44070200 |
| الوصول الحر: | https://doaj.org/article/66d6a8e9e15744eca6e4775d486dd04bTest |
| رقم الانضمام: | edsdoj.66d6a8e9e15744eca6e4775d486dd04b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14673045 14673037 |
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| DOI: | 10.3390/cimb44070200 |