Neuroprotective Mechanisms of the ACE2–Angiotensin-(1-7)–Mas Axis in Stroke
| العنوان: | Neuroprotective Mechanisms of the ACE2–Angiotensin-(1-7)–Mas Axis in Stroke |
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| المؤلفون: | Colin Sumners, Emily Haltigan, Douglas M. Bennion, Robert W. Regenhardt, U. Muscha Steckelings |
| المصدر: | Bennion, D M, Haltigan, E, Regenhardt, R W, Steckelings, U M & Sumners, C 2015, ' Neuroprotective Mechanisms of the ACE2-Angiotensin-(1-7)-Mas Axis in Stroke ', Current Hypertension Reports, vol. 17, 3 . https://doi.org/10.1007/s11906-014-0512-2Test |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Peptide Fragments/metabolism, medicine.medical_specialty, Angiotensin receptor, Angiotensin type 1 receptor, Peptidyl-Dipeptidase A, Neuroprotection, Article, Ischemia, Peptidyl-Dipeptidase A/metabolism, Signal Transduction/drug effects, Internal medicine, Internal Medicine, Humans, Animals, Medicine, Angiotensin converting enzyme 2, Receptor, Inflammation, Angiotensin II receptor type 1, biology, business.industry, Angiotensin I/metabolism, Angiotensin-converting enzyme, Angiotensin-(1-7), Neuron, Angiotensin II, Peptide Fragments, Stroke, Neuroprotective Agents, Mas, Endocrinology, Stroke/metabolism, Angiotensin type 2 receptor, Angiotensin-converting enzyme 2, biology.protein, Angiotensin-Converting Enzyme 2, Microglia, Angiotensin I, Intracerebral hemorrhage, Renin-angiotensin system, Signal transduction, business, Neuroprotective Agents/pharmacology, Neuroscience, hormones, hormone substitutes, and hormone antagonists, Signal Transduction |
| الوصف: | The discovery of beneficial neuroprotective effects of the angiotensin converting enzyme 2-angiotensin-(1-7)-Mas axis [ACE2-Ang-(1-7)-Mas] in ischemic and hemorrhagic stroke has spurred interest in a more complete characterization of its mechanisms of action. Here, we summarize findings that describe the protective role of the ACE2-Ang-(1-7)-Mas axis in stroke, along with a focused discussion on the potential mechanisms of neuroprotective effects of Ang-(1-7) in stroke. The latter incorporates evidence describing the actions of Ang-(1-7) to counter the deleterious effects of angiotensin II (AngII) via its type 1 receptor, including anti-inflammatory, anti-oxidant, vasodilatory, and angiogenic effects, and the role of altered kinase-phosphatase signaling. Interactions of Mas with other receptors, including bradykinin receptors and AngII type 2 receptors are also considered. A more complete understanding of the mechanisms of action of Ang-(1-7) to elicit neuroprotection will serve as an essential step toward research into potential targeted therapeutics in the clinical setting. |
| تدمد: | 1534-3111 1522-6417 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c1945c53f615b30ce4edda2ff3a6b6Test https://doi.org/10.1007/s11906-014-0512-2Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....98c1945c53f615b30ce4edda2ff3a6b6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15343111 15226417 |
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