AT2 Receptors Targeting Cardiac Protection Post-Myocardial Infarction
| العنوان: | AT2 Receptors Targeting Cardiac Protection Post-Myocardial Infarction |
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| المؤلفون: | Thomas Unger, Dilyara Lauer, Elena Kaschina, U. Muscha Steckelings, Patrick Schmerler |
| المساهمون: | Bedrijfsbureau CD, RS: CARIM - R3 - Vascular biology |
| المصدر: | Kaschina, E, Lauer, D, Schmerler, P, Unger, T & Steckelings, U M 2014, ' AT2 Receptors Targeting Cardiac Protection Post-Myocardial Infarction ', Current Hypertension Reports, vol. 16, no. 7, 441 . https://doi.org/10.1007/s11906-014-0441-0Test Current Hypertension Reports, 16(7):441. Current Medicine Group |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Nephrology, Cardiac function curve, medicine.medical_specialty, endocrine system, Myocardial Infarction/drug therapy, Cardiomegaly, Stimulation, Receptor, Angiotensin, Type 2, Receptor, Angiotensin, Type 1, Receptor, Angiotensin, Type 2/metabolism, Receptor, Angiotensin, Type 1/metabolism, Angiotensin Receptor Antagonists, Angiotensin, Cardiomegaly/drug therapy, Internal medicine, AT2-receptor, Renin–angiotensin system, Internal Medicine, Medicine, Animals, Humans, Myocardial infarction, Ventricular remodeling, Receptor, business.industry, Hypertension/drug therapy, Left ventricular remodeling, respiratory system, medicine.disease, Angiotensin Receptor Antagonists/therapeutic use, Blockade, Cardiac hypertrophy, Hypertension, Cardiology, cardiovascular system, business, hormones, hormone substitutes, and hormone antagonists, circulatory and respiratory physiology |
| الوصف: | The angiotensin AT2-receptor mediates tissue protective actions. Its regenerative potential has been tested in multiple disease models including models of myocardial infarction. These studies used different experimental approaches in order to detect AT2-receptor-related effects such as AT2-receptor deficiency or overexpression, treatment with an AT1-receptor blocker leading to indirect stimulation of the unopposed AT2-receptor, or studies using AT2-receptor agonists. It is a common finding in these studies that the AT2-receptor improves cardiac function in the early phase post-MI, and that this effect is preserved over periods of up to four months. Depending on the experimental protocol, the AT2R also attenuates post-MI left ventricular remodeling or protects the heart from early left ventricular thinning and rupture. In combination with AT1-receptor blockade or deficiency, post-MI cardiac hypertrophy is reduced. This article reviews studies on the role of the AT2-receptor in myocardial infarction with an emphasis on the most recent data obtained in studies using AT2-receptor agonists. |
| اللغة: | English |
| تدمد: | 1522-6417 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6972eefd5fe2c0afff06f47f63049fTest https://doi.org/10.1007/s11906-014-0441-0Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....3d6972eefd5fe2c0afff06f47f63049f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15226417 |
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