The Developmental Origins of Osteoporosis
| العنوان: | The Developmental Origins of Osteoporosis |
|---|---|
| المؤلفون: | Nicholas D. Embleton, Charlotte Stenson, Claire L Wood |
| المصدر: | Current Genomics Scopus-Elsevier |
| بيانات النشر: | Bentham Science Publishers Ltd., 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Gerontology, medicine.medical_specialty, business.industry, Public health, Osteoporosis, Alternative medicine, Osteoporosis prevention, Life course, medicine.disease, Article, Birth size, Bone mineral density, Programming, Genetics, medicine, Life course approach, business, Genetics (clinical) |
| الوصف: | Osteoporosis is one of the most prevalent skeletal disorders and has enormous public health consequences due to the morbidity and mortality of the resulting fractures. This article discusses the developmental origins of osteoporosis and outlines some of the modifiable and non-modifiable risk factors in both intrauterine and postnatal life that contribute to the later onset of osteoporosis. Evidence for the effects of birth size and early growth in both preterm and term born infants are discussed and the role of epigenetics within the programming hypothesis is highlighted. This review provides compelling evidence for the developmental origins of osteoporosis and highlights the importance of osteoporosis prevention at all stages of the life course. |
| تدمد: | 1389-2029 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2d9b915ed42792ac1a94cfe1bab0f2Test https://doi.org/10.2174/1389202916666150817202217Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5d2d9b915ed42792ac1a94cfe1bab0f2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13892029 |
|---|