Treatment of HCV in Patients who Failed First-Generation PI Therapy: a Review of Current Literature
| العنوان: | Treatment of HCV in Patients who Failed First-Generation PI Therapy: a Review of Current Literature |
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| المؤلفون: | Paul Y. Kwo, Maaz B. Badshah |
| المصدر: | Current Gastroenterology Reports. 17 |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Ledipasvir, Daclatasvir, Sofosbuvir, viruses, Alpha interferon, Interferon alpha-2, Pharmacology, Antiviral Agents, Polyethylene Glycols, Telaprevir, chemistry.chemical_compound, Clinical Trials, Phase II as Topic, Boceprevir, Drug Resistance, Viral, Ribavirin, Humans, Medicine, Protease Inhibitors, Treatment Failure, business.industry, Gastroenterology, Interferon-alpha, virus diseases, General Medicine, Hepatitis C, Hepatitis C, Chronic, biochemical phenomena, metabolism, and nutrition, medicine.disease, Recombinant Proteins, digestive system diseases, Clinical Trials, Phase III as Topic, chemistry, Drug Therapy, Combination, business, medicine.drug |
| الوصف: | The addition of the first direct-acting antiviral agents, the NS3 protease inhibitors boceprevir or telaprevir, to peg interferon and ribavirin was a major advance in the treatment of genotype 1 hepatitis C individuals with sustained virological response (SVR) rates of 63-75 %. Those who did not achieve SVR had high rates of resistance-associated variants against NS3 protease domain. Retreatment options for those who have failed first-generation protease inhibitors generally are guided by retreatment with direct-acting antiviral agents from other classes. Phase 2 and phase 3 data have demonstrated that retreatment with 12-24 weeks of a NS5B inhibitor (sofosbuvir) in combination with a NS5a inhibitor (daclatasvir or ledipasvir) with or without ribavirin can achieve SVR at high rates comparable to treatment-naive individuals. |
| تدمد: | 1534-312X 1522-8037 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14aaf9bff638134649937acf38cb04c2Test https://doi.org/10.1007/s11894-015-0462-0Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....14aaf9bff638134649937acf38cb04c2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1534312X 15228037 |
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