التفاصيل البيبلوغرافية
| العنوان: |
The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms. |
| المؤلفون: |
Leete, Pia, Mallone, Roberto, Richardson, Sarah J., Sosenko, Jay M., Redondo, Maria J., Evans-Molina, Carmella |
| المصدر: |
Current Diabetes Reports; Nov2018, Vol. 18 Issue 11, p1-1, 1p |
| مستخلص: |
Purpose Of Review: To explore the impact of age on type 1 diabetes (T1D) pathogenesis.Recent Findings: Children progress more rapidly from autoantibody positivity to T1D and have lower C-peptide levels compared to adults. In histological analysis of post-mortem pancreata, younger age of diagnosis is associated with reduced numbers of insulin containing islets and a hyper-immune CD20hi infiltrate. Moreover compared to adults, children exhibit decreased immune regulatory function and increased engagement and trafficking of autoreactive CD8+ T cells, and age-related differences in β cell vulnerability may also contribute to the more aggressive immune phenotype observed in children. To account for some of these differences, HLA and non-HLA genetic loci that influence multiple disease characteristics, including age of onset, are being increasingly characterized. The exception of T1D as an autoimmune disease more prevalent in children than adults results from a combination of immune, metabolic, and genetic factors. Age-related differences in T1D pathology have important implications for better tailoring of immunotherapies. [ABSTRACT FROM AUTHOR] |
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Copyright of Current Diabetes Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
