Gindarudine (GN), a morphine alkaloid isolated from the tubers of Stephania glabra (Menispermaceae), was evaluated for analgesic and antipyretic activities because of closely resembling structure to that of thebaine. The analgesic activity of GN was evaluated on albino mice by hot plate and tail immersion methods whereas antipyretic activity was studied on Brewer's yeast-induced pyrexia rats. Fever was induced by injecting 20 ml/kg (s.c.) of 20% aqueous suspen- sion of Brewer's yeast in normal saline and rectal temperature was recorded by clinical thermometer immediately before (- 18 h) and 18 h after (0 h) yeast administration. GN at doses of 100 and 150 mg/kg, p.o. showed significant analgesic ac- tivity (p
