Arsenic Exposure and Cardiovascular Disease:An Updated Systematic Review
| العنوان: | Arsenic Exposure and Cardiovascular Disease:An Updated Systematic Review |
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| المؤلفون: | Ana Navas-Acien, Katherine A. Moon, Eliseo Guallar |
| المصدر: | Current Atherosclerosis Reports. 14:542-555 |
| بيانات النشر: | Springer Science and Business Media LLC, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Risk, medicine.medical_specialty, Pathology, Arterial disease, chemistry.chemical_element, Disease, Article, Arsenic, Internal medicine, medicine, Humans, ARSENIC EXPOSURE, Stroke, General Environmental Science, Arsenic toxicity, Exposure Category, business.industry, Incidence, Environmental Exposure, Environmental exposure, medicine.disease, Confidence interval, Epidemiologic Studies, chemistry, Cardiovascular Diseases, Meta-analysis, Relative risk, General Earth and Planetary Sciences, Cardiology and Cardiovascular Medicine, business |
| الوصف: | In epidemiologic studies, high-chronic arsenic exposure has been associated with cardiovascular disease, despite methodological limitations. At low-moderate arsenic levels, the evidence was inconclusive. Here, we update a previous systematic review (Am J Epidemiol 2005;162: 1037–49) examining the association between arsenic exposure and cardiovascular disease. Eighteen studies published since 2005 were combined with 13 studies from the previous review. We calculated pooled relative risks by comparing the highest versus the lowest exposure category across studies. For high exposure (arsenic in drinking water > 50 μg/L), the pooled relative risks (95 % confidence interval) for cardiovascular disease, coronary heart disease, stroke, and peripheral arterial disease were 1.32 (95 % CI: 1.05–1.67), 1.89 (95 % CI: 1.33–2.69), 1.08 (95 % CI: 0.98–1.19), and 2.17 (95 % CI: 1.47–3.20), respectively. At low-moderate arsenic levels, the evidence was inconclusive. Our review strengthens the evidence for a causal association between high-chronic arsenic exposure and clinical cardiovascular endpoints. Additional high quality studies are needed at low-moderate arsenic levels. |
| تدمد: | 1534-6242 1523-3804 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::403a5363399f38df75612b4b200a6599Test https://doi.org/10.1007/s11883-012-0280-xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....403a5363399f38df75612b4b200a6599 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15346242 15233804 |
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