التفاصيل البيبلوغرافية
| العنوان: |
Association of blood component ratios with 24-hour mortality in injured children receiving massive transfusion |
| المؤلفون: |
Butler, Elissa K., Mills, Brianna M., Arbabi, Saman, Bulger, Eileen M., Vavilala, Monica S., Groner, Jonathan I., Stansbury, Lynn G., Hess, John R., Rivara, Frederick P. |
| المصدر: |
Crit Care Med |
| سنة النشر: |
2019 |
| مصطلحات موضوعية: |
Article, demo, socio |
| الوصف: |
OBJECTIVE: To determine if higher fresh frozen plasma (FFP) and platelet to packed red blood cell (PRBC) ratios are associated with lower 24-hour mortality in bleeding pediatric trauma patients. DESIGN: Retrospective cohort study using the Pediatric Trauma Quality Improvement Program Database from 2014 to 2016. SETTING: Level I and II pediatric trauma centers participating in the Trauma Quality Improvement Program PATIENTS: Injured children (≤14 years) who received massive transfusion (≥40 mL/kg total blood products in 24 hours). Of 123, 836 patients, 590 underwent massive transfusion, of which 583 met inclusion criteria. EXPOSURES: ratios of FFP:PRBC and platelet:PRBC MEASUREMENTS AND MAIN RESULTS: Of the 583 patients, 60% were male and the median age was 5 (IQR 2 to 10) years. Overall mortality was 19.7% (95% CI: 16.6 to 23.2%) at 24 hours. There was 51% (aRR 0.49, 95% CI: 0.27 to 0.87, p=0.02) and 40% (aRR 0.60, 95% CI: 0.39 to 0.92, p=0.02) lower risk of death at 24 hours for the high (≥1:1) and medium (≥1:2 and <1:1) FFP:PRBC ratio groups, respectively, compared to the low ratio group (<1:2). Platelet:PRBC ratio was not associated with mortality (aRR: 0.94, 95% CI 0.51 to 1.71, p=0.83). CONCLUSIONS: Higher FFP ratios were associated with lower 24-hour mortality in massively transfused pediatric trauma patients. The platelet ratio was not associated with mortality. While these findings represent the largest study evaluating blood product ratios in pediatric trauma patients, prospective studies are necessary to determine the optimum blood product ratios to minimize mortality in this population. |
| نوع الوثيقة: |
text |
| اللغة: |
English |
| العلاقة: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581209Test/ |
| الإتاحة: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581209Test/ |
| حقوق: |
undefined |
| رقم الانضمام: |
edsbas.7EC424A1 |
| قاعدة البيانات: |
BASE |
