التفاصيل البيبلوغرافية
| العنوان: |
Cross–regulatory interactions between Fgf8 and Shh in the avian frontonasal prominence. |
| المؤلفون: |
Abzhanov, Arhat, Cordero, Dwight R., Sen, Jonaki, Tabin, Clifford J., Helms, Jill A. |
| المصدر: |
Congenital Anomalies; Dec2007, Vol. 47 Issue 4, p136-148, 13p, 8 Black and White Photographs |
| مستخلص: |
The frontonasal prominence of the developing avian embryo contains an organizing center, defined by juxtaposition of the Sonic hedgehog ( Shh) and Fibroblast growth factor 8 ( Fgf8) expression domains. This molecular interface presages any detectable growth of the frontonasal prominence, and experiments involving transplantation of this boundary epithelium have demonstrated it is a source of dorsal-ventral and rostral-caudal patterning information for the neural crest-derived mesenchyme of the upper beak. We explored the ontogeny of this organizing center by mapping the expression domains of both genes and their receptors and downstream targets. We tested the extent to which Shh and Fgf8 regulate each other's expression in this frontonasal organizer by either blocking or ectopically activating these pathways. Our experiments revealed mutual antagonism between the two molecules, which aids in establishing and maintaining a molecular boundary that subsequently influences patterning and growth of the middle and upper face. [ABSTRACT FROM AUTHOR] |
|
Copyright of Congenital Anomalies is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
