G Protein-Coupled Receptor Systems and Their Role in Cellular Senescence
| العنوان: | G Protein-Coupled Receptor Systems and Their Role in Cellular Senescence |
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| المؤلفون: | Hanne Leysen, Jhana O. Hendrickx, Paula Santos-Otte, Stuart Maudsley, Jaana van Gastel, Bronwen Martin |
| المصدر: | Computational and Structural Biotechnology Journal Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 1265-1277 (2019) |
| بيانات النشر: | Elsevier BV, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Aging, Review Article, Disease, Aging disorders, Biochemistry, vascular smooth muscle cells, (VSMC), cyclin-dependent kinase inhibitor 1, (cdkn1A/p21), 0302 clinical medicine, Structural Biology, Hutchinson–Gilford progeria syndrome, (HGPS), purinergic receptors family, (P2Y), protein kinases, (PK), beta2-adrenergic receptor, (β2AR), Receptor, endothelial cell differentiation gene, (Edg), nuclear factor kappa-light-chain-enhancer of activated B cells, (NF- κβ), senescence associated secretory phenotype, (SASP), 0303 health sciences, Relaxin family receptor 3, (RXFP3), tumor suppressor gene PTEN, (PTEN), transcription factor E2F3, (E2F3), Computer Science Applications, Cell biology, retinoblastoma, (RB), Chemistry, 030220 oncology & carcinogenesis, G protein-coupled receptor kinase, (GRK), latent semantic indexing, (LSI), Lysophosphatidic acid, (LPA), G protein-coupled receptors (GPCRs), G protein-coupled receptor kinase interacting protein 2 (GIT2), mitogen-activated protein kinase, (MAPK), Regulator of G-protein signaling, (RGS), Engineering sciences. Technology, AT1R blockers, (ARB), Biotechnology, Cell signaling, lcsh:Biotechnology, renin-angiotensin system, (RAS), Biophysics, Cellular senescence, tumor suppressor protein 53, (p53), Biology, 03 medical and health sciences, Cell surface receptor, lcsh:TP248.13-248.65, angiotensin type 2 receptor, (AT2R), Genetics, G protein-coupled receptor kinase interacting protein 2, (GIT2), Ataxia telangiectasia mutated, (ATM), Angiotensin II, (Ang II), 030304 developmental biology, G protein-coupled receptor, inactive state, (R), angiotensin type 1 receptor, (AT1R), G protein-coupled receptors, (GPCRs), β-Arrestin, ADP-ribosylation factor GTPase-activating protein, (Arf-GAP), cyclin-dependent kinase 2, (CDK2), Apoptosis, transmembrane, (TM), stress-induced premature senescence, (SIPS), active state, (R*) |
| الوصف: | Aging is a complex biological process that is inevitable for nearly all organisms. Aging is the strongest risk factor for development of multiple neurodegenerative disorders, cancer and cardiovascular disorders. Age-related disease conditions are mainly caused by the progressive degradation of the integrity of communication systems within and between organs. This is in part mediated by, i) decreased efficiency of receptor signaling systems and ii) an increasing inability to cope with stress leading to apoptosis and cellular senescence. Cellular senescence is a natural process during embryonic development, more recently it has been shown to be also involved in the development of aging disorders and is now considered one of the major hallmarks of aging. G-protein-coupled receptors (GPCRs) comprise a superfamily of integral membrane receptors that are responsible for cell signaling events involved in nearly every physiological process. Recent advances in the molecular understanding of GPCR signaling complexity have expanded their therapeutic capacity tremendously. Emerging data now suggests the involvement of GPCRs and their associated proteins in the development of cellular senescence. With the proven efficacy of therapeutic GPCR targeting, it is reasonable to now consider GPCRs as potential platforms to control cellular senescence and the consequently, age-related disorders. Graphical Abstract Unlabelled Image |
| وصف الملف: | |
| تدمد: | 2001-0370 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df108c2d57f738f31f95e73a11100b3Test https://doi.org/10.1016/j.csbj.2019.08.005Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6df108c2d57f738f31f95e73a11100b3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20010370 |
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