التفاصيل البيبلوغرافية
| العنوان: |
Nano curcumin supplementation reduced the severity of diabetic sensorimotor polyneuropathy in patients with type 2 diabetes mellitus: A randomized double-blind placebo- controlled clinical trial. |
| المؤلفون: |
Asadi, Sara, Gholami, Mohammad Saeed, Siassi, Fereydoun, Qorbani, Mostafa, Khamoshian, Kianoosh, Sotoudeh, Gity |
| المصدر: |
Complementary Therapies in Medicine; Apr2019, Vol. 43, p253-260, 8p |
| مستخلص: |
Background: Diabetic Sensorimotor Polyneuropathy (DSPN) is a common complication of diabetes mellitus. Curcumin is the most important ingredient found in turmeric which has a very high potential for eliminating free radicals and inhibiting oxidative stress as an antioxidant agent. The aim of this study was to determine the effect of Nano-curcumin supplementation on the severity of sensorimotor polyneuropathy in patients with Type 2 diabetes mellitus (T2DM).Method: This parallel, double-blind randomized, placebo-controlled clinical trial was conducted on 80 diabetic patients. Participants were allocated randomly to the intervention (n = 40) and the control group (n = 40). They received 80 mg of nano-curcumin or placebo capsules for 8 weeks. Anthropometric measurements, dietary intake, physical activity, glycemic indices and the severity of DSPN were measured before and after the intervention.Result: Supplementation of nano curcumin was accounted for a significant reduction in Glycated hemoglobin(HbA1c) (p < 0.001) and Fast Blood Sugar(FBS) (p = 0.004), total score of neuropathy (p < 0.001), total reflex score (p = 0.04) and temperature (p = 0.01) compared to placebo group.Conclusion: Our findings indicated that curcumin supplementation for 2 months improved and reduced the severity of DSPN in patients with T2DM. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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