التفاصيل البيبلوغرافية
| العنوان: |
Effect of sodium arsenite on the expression of GSTM1, GSTT1 and GSTO2. |
| المؤلفون: |
Saadat, Iraj, Saadat, Mostafa |
| المصدر: |
Comparative Clinical Pathology; Nov2013, Vol. 22 Issue 6, p1061-1063, 3p |
| مصطلحات موضوعية: |
SODIUM arsenite, GENE expression, GLUTATHIONE transferase, ARSENIC metabolism, HELA cells, EPIDEMIOLOGY, MESSENGER RNA |
| مستخلص: |
Epidemiological studies have shown that arsenic exposure is associated with several diseases including cancers. Since glutathione S-transferases (GSTs) are involved in the metabolism of inorganic arsenic, the aim of the present study was to demonstrate the expression level of GSTM1 (a member of GST class mu), GSTT1 (a member of GST class theta) and GSTO2 (a member of GST class omega) genes in HeLa cell line in response to sodium arsenite. In order to determine whether the GSTM1, GSTT1 and GSTO2 mRNA are transcriptionally regulated by sodium arsenite, HeLa cells were treated at a final concentration 2 μM sodium arsenite for 24 h. The expression level of GSTM1, GSTT1 and GSTO2 was determined using quantitative real-time PCR. The results demonstrated that sodium arsenite did not change the expression level of these GST metabolising enzymes. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
