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Glycosylphosphatidylinositols: More than just an anchor?

التفاصيل البيبلوغرافية
العنوان: Glycosylphosphatidylinositols: More than just an anchor?
المؤلفون: Clive Bate, William Nolan, Alun Williams
المصدر: Communicative & Integrative Biology, Vol 9, Iss 2 (2016)
بيانات النشر: Taylor & Francis Group, 2016.
سنة النشر: 2016
المجموعة: LCC:Biology (General)
مصطلحات موضوعية: cholesterol, glycosylphosphatidylinositols, phospholipase A2, sialic acid, Biology (General), QH301-705.5
الوصف: There is increasing interest in the role of glycosylphosphatidylinositol (GPI) anchors that attach some proteins to cell membranes. Far from being biologically inert, GPIs influence the targeting, intracellular trafficking and function of the attached protein. Our recent paper demonstrated the role of sialic acid on the GPI of the cellular prion protein (PrPC). The “prion diseases” arise following the conversion of PrPC to a disease-associated isoform called PrPSc or “prion”. Our paper showed that desialylated PrPC inhibited PrPSc formation. Aggregated PrPSc creates a signaling platform in the cell membrane incorporating and activating cytoplasmic phospholipase A2 (cPLA2), an enzyme that regulates PrPC trafficking and hence PrPSc formation. The presence of desialylated PrPC caused the dissociation of cPLA2 from PrP-containing platforms, reduced the activation of cPLA2 and inhibited PrPSc production. We concluded that sialic acid contained within the GPI attached to PrPC modifies local membrane microenvironments that are important in PrP-mediated cell signaling and PrPSc formation.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1942-0889
19420889
العلاقة: https://doaj.org/toc/1942-0889Test
DOI: 10.1080/19420889.2016.1149671
الوصول الحر: https://doaj.org/article/9805540383d643058d99783cb5032a56Test
رقم الانضمام: edsdoj.9805540383d643058d99783cb5032a56
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19420889
DOI:10.1080/19420889.2016.1149671