التفاصيل البيبلوغرافية
| العنوان: |
B005 Tumour Cells in Peri-Tumoural Fibrosis after Neoadjuvant Treatment in Locally Advanced Rectal Cancer. |
| المؤلفون: |
Tanaka, S., Palmer, G., Martling, A., Lindholm, J., Holm, T. |
| المصدر: |
Colorectal Disease; Sep2006 Supplement 4, Vol. 8, p2-2, 1p |
| مصطلحات موضوعية: |
RECTAL cancer, CANCER histopathology, FIBROSIS, TUMORS, METASTASIS |
| مستخلص: |
Objective In patients with locally advanced (T4) rectal cancer extended resections are usually performed to achieve R0 resection. A significant downsizing and downstaging is often seen after neoadjuvant treatment and histopathological assessment may reveal a T0–T3 tumour with fibrosis between the tumour and the adjacent resected structure. Provided this fibrosis does not contain tumour cells, a less extensive, organ preserving, resection would be preferable in such patients. The aim of this study was to assess the presence of tumour cells within the peri-tumoural fibrosis Method A total of 53 patients with locally advanced (T4) rectal cancer according to clinical and/or radiological evaluation were treated with preoperative radiotherapy or radio-chemotherapy. Extensive surgery, including resection of another structure or organ was performed based on the pretreatment assessment. Histopathological examination was performed using routine staining supplemented by immunohistochemistry (CK 20). Results Scattered tumour cells within the fibrosis, at or outside the mesorectal fascia, were found in 26 patients and in the remaining patients no tumour cells were found. Conclusion Although neoadjuvant treatment often induces fibrosis and downsizes locally advanced rectal cancer, less extensive resections (i.e. TME alone) cannot be advocated since the peri-tumoural fibrosis contains tumour cells in 50% of the patients. [ABSTRACT FROM AUTHOR] |
|
Copyright of Colorectal Disease is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
