Effects of thyroxine replacement on endothelial function and carotid artery intima-media thickness in female patients with mild subclinical hypothyroidism
| العنوان: | Effects of thyroxine replacement on endothelial function and carotid artery intima-media thickness in female patients with mild subclinical hypothyroidism |
|---|---|
| المؤلفون: | Cabral, Monica Dias, Teixeira, Patricia, Soares, Debora, Leite, Sandra, Salles, Elizabeth, Waisman, Mario |
| المصدر: | Clinics Clinics, Vol 66, Iss 8, Pp 1321-1328 (2011) Clinics; v. 66 n. 8 (2011); 1321-1328 Clinics; Vol. 66 Núm. 8 (2011); 1321-1328 Clinics; Vol. 66 No. 8 (2011); 1321-1328 Universidade de São Paulo (USP) instacron:USP Clinics, Volume: 66, Issue: 8, Pages: 1321-1328, Published: 2011 |
| بيانات النشر: | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, Male, lcsh:R5-920, Hormone Replacement Therapy, Thyrotropin, Endothelial function, Clinical Science, Middle Aged, Carotid Intima-Media Thickness, Vasodilation, Thyroxine, Hypothyroidism, Subclinical hypothyroidism, Levothyroxine treatment, Regional Blood Flow, Flow-mediated vasodilatation, Carotid artery intima-media thickness, Humans, Female, Endothelium, Vascular, Prospective Studies, lcsh:Medicine (General), Follow-Up Studies |
| الوصف: | BACKGROUND: Previous studies have suggested an association between subclinical hypothyroidism and coronary artery disease that could be related to changes in serum lipids or endothelial dysfunction. METHODS: Thirty-two female subclinical hypothyroidism patients were randomly assigned to 12 months of L-thyroxine replacement or no treatment. Endothelial function was measured by the flow-mediated vasodilatation of the brachial artery, as well as mean carotid artery intima-media thickness, and lipid profiles were studied at baseline and after 12 months of follow-up. RESULTS: The mean ( ± SD) serum thyroid-stimulating hormone levels in the L-thyroxine replacement and control groups were 6.09±1.32 and 6.27 ± 1.39 μUI/ml, respectively. No relationship between carotid artery intima-media thickness or brachial flow-mediated vasodilatation and free T4 and serum thyroid-stimulating hormone was found. The median L-T4 dose was 44.23 ± 18.13 μg/day. After 12 months, there was a significant decrease in the flow-mediated vasodilatation in the subclinical hypothyroidism control group (before: 17.33 ± 7.88 to after: 13.1 ±4.75%, p =0.03), but there were no significant differences in flow-mediated vasodilatation in the L-thyroxine treated group (before: 16.81 ± 7.0 to after: 18.52 ± 7.44%, p = 0.39). We did not find any significant change in mean carotid intimamedia thickness after 12 months of L-thyroxine treatment. CONCLUSION: Replacement therapy prevents a decline in flow-mediated vasodilatation with continuation of the subclinical hypothyroidism state. Large prospective multicenter placebo-controlled trials are necessaryto investigate endothelial physiology further in subclinical hypothyroidism patients and to define the role of L-thyroxine therapy in improving endothelial function in these patients. |
| وصف الملف: | application/pdf; text/html |
| اللغة: | English |
| تدمد: | 1980-5322 1807-5932 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8c7794e7f26623a3b83a38a933ba4d08Test http://europepmc.org/articles/PMC3161206Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....8c7794e7f26623a3b83a38a933ba4d08 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19805322 18075932 |
|---|