المصدر: Clinical Trials Week; 6/10/2024, p814-814, 1p

مصطلحات موضوعية: STROKE patients, STROKE, CEREBRAL anoxia-ischemia, LONGITUDINAL method, COHORT analysis, CEREBROVASCULAR disease

مصطلحات جغرافية: BEIJING (China)

مستخلص: A report from Capital Medical University in Beijing, China discusses the use of endovascular cooling in patients with large acute ischemic strokes (AIS) after recanalization. The study analyzed AIS patients who achieved successful recanalization after endovascular treatment and were divided into a targeted temperature management (TTM) group and a non-TTM group. The TTM group received systemic cooling with a targeted core temperature of 33 degrees for at least 48 hours. The study found that the TTM group had a higher proportion of favorable outcomes at 90 days compared to the non-TTM group, although there were no significant differences in secondary outcomes. The researchers concluded that further randomized clinical trials are needed to validate the efficacy of postrecanalization cooling in patients with a large ischemic core. [Extracted from the article]

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المصدر: Clinical Trials Week; 6/10/2024, p1786-1786, 1p

مصطلحات موضوعية: CEREBRAL ischemia, CONGENITAL disorders, HUMAN abnormalities, INFANTS, CENTRAL nervous system diseases, CEREBRAL anoxia-ischemia

مستخلص: A study conducted by the University of California San Francisco (UCSF) examined the impact of genetic and congenital anomalies on infants with hypoxic-ischemic encephalopathy (HIE), a condition caused by oxygen deprivation during labor and delivery. The study found that infants with HIE and genetic or congenital anomalies had worse neurodevelopmental outcomes compared to infants with HIE alone. These infants were more likely to experience death or neurodevelopmental impairment, be diagnosed with cerebral palsy, and have lower scores in motor, cognitive, and language domains. The research was supported by the NIH National Institute of Neurological Disorders & Stroke. [Extracted from the article]

: Copyright of Clinical Trials Week is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المصدر: Clinical Trials Week; 5/6/2024, p1780-1780, 1p

مصطلحات موضوعية: CEREBRAL palsy, EPILEPSY, CEREBRAL anoxia-ischemia, COHORT analysis, CENTRAL nervous system diseases, LONGITUDINAL method, NEWBORN infants

مصطلحات جغرافية: MADHYA Pradesh (India)

مستخلص: A new report from Madhya Pradesh, India presents fresh data on cerebral palsy. The research focuses on the role of early Electroencephalogram (EEG) background activity in predicting cerebral palsy, epilepsy, and developmental delay in term newborns with Hypoxic Ischaemic Encephalopathy (HIE). The study found that EEG within six hours of birth in term neonates with HIE has a high sensitivity and negative predictive value in predicting short-term and long-term outcomes, including death, poor neurological outcome, cerebral palsy, epilepsy, and developmental delay. This information can be valuable for parental counseling, resource allocation, and early intervention services. [Extracted from the article]

: Copyright of Clinical Trials Week is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المصدر: Clinical Trials Week; 5/6/2024, p338-338, 1p

مصطلحات موضوعية: CARDIOPULMONARY resuscitation, COLD therapy, RESEARCH personnel, TREATMENT effectiveness, HYPOTHERMIA, EMERGENCY nursing, CEREBRAL anoxia-ischemia

مستخلص: A recent study conducted at Fujian Provincial Hospital South Branch in Fuzhou, China, aimed to investigate the impact of optimized emergency nursing in conjunction with mild hypothermia nursing on neurological prognosis, hemodynamics, and complications in patients with cardiac arrest. The study analyzed the medical records of 124 patients who received successful cardiopulmonary resuscitation (CPR). The results showed that the integration of optimized emergency nursing practices in conjunction with CPR improved neurological outcomes in patients with cardiac arrest. Additionally, the implementation of optimized nursing practices significantly reduced complications and improved the quality of life and satisfaction of post-CPR patients. [Extracted from the article]

: Copyright of Clinical Trials Week is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المصدر: Clinical Trials Week; 4/30/2024, p466-466, 1p

مصطلحات موضوعية: BRAIN injuries, TEMPERATURE control, BRAIN research, CEREBRAL anoxia-ischemia, CENTRAL nervous system injuries, CENTRAL nervous system diseases

الشركة/الكيان: UNIVERSITY of Washington

مستخلص: A new report from the University of Washington discusses the role of temperature control in severe acute brain injury (SABI), including conditions such as traumatic brain injury, acute ischemic stroke, intracerebral hemorrhage, aneurysmal subarachnoid hemorrhage, and hypoxemic/ischemic brain injury following cardiac arrest. Fever is a common complication in SABI and is associated with worse neurological outcomes. Hypothermic temperature control (HTC) appears to mitigate these adverse effects by reducing cerebral metabolic demand and dampening inflammatory pathways, but its effectiveness varies across different SABI conditions. Further research is needed to establish optimal temperature management strategies. [Extracted from the article]

: Copyright of Clinical Trials Week is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المصدر: Clinical Trials Week; 3/11/2024, p2080-2080, 1p

مصطلحات موضوعية: CEREBRAL anoxia-ischemia, CEREBRAL ischemia, CENTRAL nervous system diseases, STATE universities & colleges

مصطلحات جغرافية: RIO de Janeiro (Brazil)

المصدر: Clinical Trials Week; 2024, p956-956, 1p

مصطلحات موضوعية: CEREBRAL anoxia-ischemia, CEREBRAL ischemia, ERYTHROPOIETIN, CENTRAL nervous system diseases, GOVERNMENT investigators

مستخلص: A report from Michigan State University discusses the use of erythropoietin (EPO) as a potential treatment for neonatal hypoxic-ischemic encephalopathy (HIE). The researchers conducted a systematic review and meta-analysis of studies investigating the effectiveness of EPO in treating HIE. The analysis included seven studies with 903 infants and found that EPO did not reduce the risk of death, neurodisability, or cerebral palsy. The researchers suggest that future large-scale randomized controlled trials are needed to further evaluate the safety and efficacy of EPO for the treatment of neonatal encephalopathy. [Extracted from the article]

: Copyright of Clinical Trials Week is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المصدر: Clinical Trials Week; 2024, p1137-1137, 1p

مصطلحات موضوعية: CEREBRAL anoxia-ischemia, CEREBRAL ischemia, CENTRAL nervous system diseases, NEWBORN infants, COOLING, PASSIVE euthanasia

مصطلحات جغرافية: NEBRASKA

مستخلص: A recent study conducted at the University of Nebraska examined the effects of different cooling methods during transport on short-term outcomes in newborns with hypoxic-ischemic encephalopathy (HIE). The study found that therapeutic hypothermia (TH) is the only approved treatment for HIE, and it must be initiated within 6 hours to be effective. The researchers compared active TH, which uses servo-controlled cooling, to passive hypothermia. They found that active TH resulted in tighter temperature control but did not improve short-term outcomes compared to passive cooling. The study suggests that the differences in brain injury observed on magnetic resonance imaging (MRI) may be due to variations in disease severity. [Extracted from the article]

: Copyright of Clinical Trials Week is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المصدر: Clinical Trials Week; 12/12/2023, p1286-1286, 1p

مصطلحات موضوعية: CEREBRAL anoxia-ischemia, CEREBRAL ischemia, BRAIN injuries, ERYTHROPOIETIN, CENTRAL nervous system diseases

الشركة/الكيان: UNIVERSITY of Southern California

مستخلص: A recent study conducted by the University of Southern California (USC) examined the effects of erythropoietin (Epo) on brain injury outcomes in neonates with moderate or severe hypoxic-ischemic encephalopathy (HIE). The study found that Epo did not improve overall outcomes in this population. The research analyzed neuroimaging data from the High-dose Erythropoietin for Asphyxia and Encephalopathy (HEAL) Trial, involving 500 infants. The study concluded that subacute brain injury was more common than previously reported, which has implications for the development of neuroprotective therapies for this population. [Extracted from the article]

: Copyright of Clinical Trials Week is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المصدر: Clinical Trials Week; 10/9/2023, p1726-1726, 1p

مصطلحات موضوعية: CEREBRAL anoxia-ischemia, CEREBRAL ischemia, THERAPEUTIC hypothermia, FENTANYL, UNIVERSITY hospitals, NEWBORN infants

مستخلص: Newborns undergoing TH receive a standard fentanyl regimen (2 mcg/Kg of fentanyl as a loading dose, followed by a continuous infusion-1 mcg/kg/h-during the 72 h of TH and subsequent rewarming). Keywords: Brain Ischemia; Central Nervous System Agents; Central Nervous System Diseases and Conditions; Drugs and Therapies; Fentanyl Therapy; Health and Medicine; Hypoxic-Ischemic Encephalopathy; Narcotic Analgesics; Pharmaceuticals EN Brain Ischemia Central Nervous System Agents Central Nervous System Diseases and Conditions Drugs and Therapies Fentanyl Therapy Health and Medicine Hypoxic-Ischemic Encephalopathy Narcotic Analgesics Pharmaceuticals 1726 1726 1 10/09/23 20231009 NES 231009 2023 OCT 9 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Researchers detail new data in brain ischemia. [Extracted from the article]

: Copyright of Clinical Trials Week is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)