التفاصيل البيبلوغرافية
| العنوان: |
Successful living donor renal transplantation despite ABO incompatibility and a positive crossmatch. |
| المؤلفون: |
Kayler, Liise K., Colombe, Beth, Farber, John L., LaCava, Deborah, Dafoe, Donald C., Burke, James F., Francos, George C., Ratner, Lloyd E. |
| المصدر: |
Clinical Transplantation; Dec2004, Vol. 18 Issue 6, p737-742, 6p, 2 Black and White Photographs, 4 Charts, 1 Graph |
| مصطلحات موضوعية: |
KIDNEY transplantation, TRANSPLANTATION of organs, tissues, etc., LIVING related donor transplantation, HOMOGRAFTS, ABO blood group system |
| مستخلص: |
Kayler LK, Colombe B, Farber JL, LaCava D, Dafoe DC, Burke JF, Francos GC, Ratner LE. Successful living donor renal transplantation despite ABO incompatibility and a positive crossmatch.Clin Transplant 2004 DOI: 10.1111/j.1399-0012.2004.00259.x© Blackwell Munksgaard, 2004Potential live kidney donors have been rejected when the prospective recipients are blood type or crossmatch incompatible. By utilizing plasmapheresis combined with intravenous immune globulin (PP/IVIg) prior to surgery, donor-specific antibodies against blood group or human leukocyte antigens (HLA) have been removed, thereby allowing successful renal transplantation. A 26-yr-old male with a panel reactive antibody level of 100% and repeated positive crossmatches against deceased donor kidney offers, including zero HLA mismatched donors, successfully underwent ABO-incompatible kidney transplantation from his HLA-identical but nevertheless crossmatch-incompatible sister. The initial anti-A blood group isoagglutinin titers were 128, 256, and 1024 at room temperature, 37°C, and 37°C anti-IgG enhanced, respectively. With an individualized PP/IVIg regimen based on donor-specific antibody titer, however, the relevant antibodies were adequately reduced and hyperacute rejection avoided. Subsequent antibody-mediated rejection, likely directed against a minor histocompatibility antigen, was diagnosed on postoperative day 7 and successfully treated. Neither ABO, or crossmatch incompatibility, or both in combination prohibit kidney transplantation. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
