التفاصيل البيبلوغرافية
| العنوان: |
Management of hepatitis C-infected liver transplant recipients at large North American centres: changes in recent years. |
| المؤلفون: |
Khalili, Mandana, Vardanian, Andrew J., Hamerski, Chris M., Rou Wang, Bacchetti, Peter, Roberts, John P., Terrault, Norah A. |
| المصدر: |
Clinical Transplantation; Jan/Feb2006, Vol. 20 Issue 1, p1-9, 9p, 3 Charts, 2 Graphs |
| مصطلحات موضوعية: |
LIVER transplantation, TRANSPLANTATION of organs, tissues, etc., HEPATITIS C virus, IMMUNOSUPPRESSION, PATIENTS, THERAPEUTICS |
| مستخلص: |
Large (≥45 transplants per year) North American liver transplant centres were surveyed regarding management of hepatitis C virus (HCV). A total of 25/41 (59%) and 28/48 (58%) of centres responded to the surveys in 1998 and 2003, respectively, with 17 centres participating in both surveys. HCV was the most common indication for transplantation. Use of protocol liver biopsies was higher in 2003 and 60% used them to monitor HCV disease. Fewer centres reported modifying primary immunosuppression (IMS) for HCV-positive (vs. non-HCV) patients in 2003 (26%) vs. 1998 (56%). IMS was most frequently tacrolimus-based, but mycophenolate mofetil use increased in 2003 (52% vs. 23% in 1998). In both years, approximately 40% treated allograft rejection differently in HCV-positive recipients, with less use of OKT3 in 2003. Combination anti-HCV therapy for 12 months or more was the treatment of choice and growth factor use was common (68%). HCV-positive recipients were considered candidates for retransplantation but HCV-specific criteria were used in decision-making. Practice of centres changed over time with an increase in HCV transplantation and use of protocol liver biopsies, and a trend towards lesser modification of IMS in HCV-positive recipients. We conclude that there is considerable variability in the management of HCV among transplant programs and over time. [ABSTRACT FROM AUTHOR] |
|
Copyright of Clinical Transplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
