Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies
| العنوان: | Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies |
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| المؤلفون: | Adam J. Lewandowski, Brenda Kelly, Laura Newton, Esther F. Davis, Theodosios Kyriakou, Paul Leeson, Merzaka Lazdam |
| المصدر: | Clinical Science (London, England : 1979) |
| بيانات النشر: | Portland Press Ltd., 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Vascular Endothelial Growth Factor A, BP, blood pressure, IMT, intima-media thickness, BMI, body mass index, Review Article, Disease, 030204 cardiovascular system & hematology, SBP, systolic BP, Bioinformatics, 0302 clinical medicine, PKCϵ, protein kinase Cϵ, Pregnancy, cardiovascular disease, HUVEC, human umbilical vein endothelial cell, Hypoxia, TGF, transforming growth factor, reproductive and urinary physiology, Sex Characteristics, 0303 health sciences, eNOS, endothelial NO synthase, blood pressure, LVH, LV hypertrophy, PlGF, placental growth factor, General Medicine, VEGF, vascular endothelial growth factor, sEng, soluble endoglin, 3. Good health, MMP, matrix metalloproteinase, sFlt-1, soluble fms-like tyrosine kinase-1, Cardiovascular Diseases, In utero, CYP, cytochrome P450, Female, Disease Susceptibility, medicine.symptom, Sex characteristics, S1, pre-eclampsia, RUPP, reduced uterine artery perfusion, Offspring, S9, Biology, in utero, vascular function, 03 medical and health sciences, L-NAME, NG-nitro-L-arginine methyl ester, ROS, reactive oxygen species, TIMP, tissue inhibitor of metalloproteinases, medicine, Animals, Humans, Epigenetics, LV, left ventricular, 030304 developmental biology, Inflammation, Eclampsia, offspring, Uterus, I/R, ischaemia/reperfusion, Hypoxia (medical), medicine.disease, Rats, IUGR, intra-uterine growth restriction, Immunology, Endothelium, Vascular |
| الوصف: | Pre-eclampsia is increasingly recognized as more than an isolated disease of pregnancy. Women who have had a pregnancy complicated by pre-eclampsia have a 4-fold increased risk of later cardiovascular disease. Intriguingly, the offspring of affected pregnancies also have an increased risk of higher blood pressure and almost double the risk of stroke in later life. Experimental approaches to identify the key features of pre-eclampsia responsible for this programming of offspring cardiovascular health, or the key biological pathways modified in the offspring, have the potential to highlight novel targets for early primary prevention strategies. As pre-eclampsia occurs in 2–5% of all pregnancies, the findings are relevant to the current healthcare of up to 3 million people in the U.K. and 15 million people in the U.S.A. In the present paper, we review the current literature that concerns potential mechanisms for adverse cardiovascular programming in offspring exposed to pre-eclampsia, considering two major areas of investigation: first, experimental models that mimic features of the in utero environment characteristic of pre-eclampsia, and secondly, how, in humans, offspring cardiovascular phenotype is altered after exposure to pre-eclampsia. We compare and contrast the findings from these two bodies of work to develop insights into the likely key pathways of relevance. The present review and analysis highlights the pivotal role of long-term changes in vascular function and identifies areas of growing interest, specifically, response to hypoxia, immune modification, epigenetics and the anti-angiogenic in utero milieu. |
| تدمد: | 1470-8736 0143-5221 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7edbb607403dce280114809349567f00Test https://doi.org/10.1042/cs20110627Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7edbb607403dce280114809349567f00 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14708736 01435221 |
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