Plasma interleukin 6 levels are associated with cardiac function after ST-elevation myocardial infarction
| العنوان: | Plasma interleukin 6 levels are associated with cardiac function after ST-elevation myocardial infarction |
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| المؤلفون: | Jacco C. Karper, Dirk J. van Veldhuisen, Erik Lipsic, Remco A. J. Schurer, Pim van der Harst, Hindrik W. van der Werf, Hilde E. Groot, Lawien Al Ali, Iwan C. C. van der Horst |
| المساهمون: | Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Cardiovascular Centre (CVC) |
| المصدر: | Clinical Research in Cardiology, 108(6), 612-621. SPRINGER HEIDELBERG Clinical Research in Cardiology |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Left ventricular ejection fraction, Time Factors, Soluble interleukin 6 receptor, Interleukin 6, 030204 cardiovascular system & hematology, Infarct size, Ventricular Function, Left, 0302 clinical medicine, Risk Factors, Cytokine Receptor gp130, Medicine, 030212 general & internal medicine, Myocardial infarction, Ejection fraction, medicine.diagnostic_test, biology, General Medicine, Middle Aged, Magnetic Resonance Imaging, Treatment Outcome, ST-elevation myocardial infarction, Echocardiography, Cardiology, Female, Cardiology and Cardiovascular Medicine, Cardiac function curve, medicine.medical_specialty, 03 medical and health sciences, Percutaneous Coronary Intervention, Soluble glycoprotein 130, St elevation myocardial infarction, Internal medicine, Humans, cardiovascular diseases, Aged, Original Paper, Interleukin-6, business.industry, Myocardium, Stroke Volume, Magnetic resonance imaging, Recovery of Function, medicine.disease, Receptors, Interleukin-6, Cardiac repair, biology.protein, ST Elevation Myocardial Infarction, business, Biomarkers |
| الوصف: | Background and aims Myocardial infarction triggers an inflammatory response involved in cardiac repair. We studied the association of the interleukin 6 (IL-6) cascade with infarct size and cardiac function after ST-elevation myocardial infarction (STEMI). Methods In 369 STEMI patients IL-6, soluble IL-6 receptor (sIL-6R), and soluble glycoprotein (sgp) 130 were measured at baseline (hospital admission), 24 h, 2 weeks, 7 weeks, 4 months, and 1 year post-PCI and sIL-6R/IL-6 ratio was calculated. At 4 months, infarct size and left ventricular ejection fraction (LVEF) were assessed by magnetic resonance imaging. Diastolic function (E/e′) was determined by echocardiography. Results Hospital admission levels for IL-6, sIL-6R, sgp 130 were 3.7 pg/ml (IQR 2.1–6.7 pg/ml), 51.6 ng/ml (IQR 37.3–69.0 ng/ml), and 332 ng/ml (IQR 280–399 ng/ml), respectively. 24 h after admission, IL-6 had increased threefold compared to baseline (p |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1861-0684 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6661e9e27023be0233f666b3981baa85Test https://hdl.handle.net/11370/5515de02-5f3a-439e-b3a1-30cc6947c1bcTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6661e9e27023be0233f666b3981baa85 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18610684 |
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