Hepatobiliary diseases have been described with increasing frequency among patients with the acquired immunodeficiency syndrome (AIDS). In patients presenting with a cholestatic pattern of liver function test abnormalities, cholangiopathy associated with human immunodeficiency virus (HIV) infection should be suspected. AIDS cholangiopathy is a syndrome of biliary obstruction usually resulting from infection-associated strictures of the biliary tract. Margulis and colleagues noted abnormal biliary tract morphology in three patients with AIDS in 1986. Since that time, many researchers have described abnormalities of intrahepatic and/or extrahepatic ducts in AIDS patients undergoing endoscopic retrograde cholangiopancreatography (ERCP). We present two cases of AIDS-related cholangiopathy in whom biliary tract changes were well demonstrated on magnetic resonance cholangiopancreatography (MRCP) images.