Clinical Characteristics of Patients with Schizophrenia Maintained without Antipsychotics: A Cross-sectional Survey of a Case Series
| العنوان: | Clinical Characteristics of Patients with Schizophrenia Maintained without Antipsychotics: A Cross-sectional Survey of a Case Series |
|---|---|
| المؤلفون: | Hideaki Tani, Masaru Mimura, Takefumi Suzuki, Hiroyuki Uchida, Masayuki Tomita |
| المصدر: | Clinical Psychopharmacology and Neuroscience |
| بيانات النشر: | Korean College of Neuropsychopharmacology, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Geriatrics, medicine.medical_specialty, Positive and Negative Syndrome Scale, Maintenance, business.industry, Cross-sectional study, Brief Report, Discontinuation, medicine.disease, Relapse prevention, Behavioral Neuroscience, Psychiatry and Mental health, Rating scale, Schizophrenia, Internal medicine, medicine, Antipsychotics, Pharmacology (medical), business, Psychopathology |
| الوصف: | Objective While antipsychotics are necessary for relapse prevention in the treatment of schizophrenia in general, some minority of patients may be maintained without continuous antipsychotic treatment. However, the characteristics of such patients are not well known and previous reports have not evaluated key elements such as physical comorbidities and functioning. Methods Among 635 patients with schizophrenia who participated in a 12-year follow-up, those who were maintained without antipsychotic treatment for at least one year after the study were investigated. The patients underwent comprehensive assessments, including Positive and Negative Syndrome Scale (PANSS) for psychopathology, Cumulative Illness Rating Scale for Geriatrics (CIRS-G) for physical comorbidities, and Functional Assessment for Comprehensive Treatment of Schizophrenia (FACT-Sz), Barthel Index, and EuroQoL five dimensions (EQ5D) for function. Results Six patients were included (mean ± standard deviation age, 66.8 ± 17.4 years; 4 inpatients). The four inpatients were old (77.8 ± 4.8 years) and chronically ill (duration of illness, 49.3 ± 12.5 years) with a high PANSS score (total score, 118.0 ± 9.8; negative syndrome subscale, 41.3 ± 6.9), low functioning (FACT-Sz, 9.8 ± 3.6; Barthel Index, 8.8 ± 9.6), and serious physical comorbidities (CIRS-G, 15.5 ± 1.1). By contrast, the two outpatients were relatively young (45.0 ± 12.0 years) and clinically in good condition (PANSS total score, 44.5 ± 0.5; Barthel Index, 100 for both; EQ5D, 0.85 ± 0.04). Conclusion Although the number is limited, two types of patients with schizophrenia were identified who were free from ongoing antipsychotic treatment; 1) older chronic inpatients with serious physical comorbidities, and 2) younger outpatients with milder impairments. Future explorations are needed to identify those who will be successfully withdrawn from continuous antipsychotic treatment. |
| تدمد: | 2093-4327 1738-1088 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff3c6502bdf93bc95d035c929f4ebc2Test https://doi.org/10.9758/cpn.2021.19.4.773Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5ff3c6502bdf93bc95d035c929f4ebc2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20934327 17381088 |
|---|