Polymorphisms in the renin-angiotensin system and endothelium-dependent vasodilation in normotensive subjects
| العنوان: | Polymorphisms in the renin-angiotensin system and endothelium-dependent vasodilation in normotensive subjects |
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| المؤلفون: | Kurland, Lisa, Melhus, Håkan, Sarabi, Mahziar, Millgård, Jonas, Ljunghall, Sverker, Lind, Lars |
| المصدر: | Clinical Physiology. 21(3):343-349 |
| مصطلحات موضوعية: | Adult, Aged, Aldosterone Synthase/genetics, Endothelium, Vascular/*physiology, Female, Gene Deletion, Humans, Male, Middle Aged, Nitroprusside/administration & dosage/pharmacology, Peptidyl-Dipeptidase A/*genetics, Polymorphism, Genetic, Restriction Fragment Length, Receptor, Angiotensin, Type 1, Type 2, Receptors, Angiotensin/genetics, Renin-Angiotensin System/*genetics, MEDICINE, MEDICIN |
| الوصف: | BACKGROUND: Our aim was to test the hypothesis that genes encoding components in the renin-angiotensin system influence endothelial vasodilatory function.METHODS: In 59 apparently healthy, normotensive individuals, endothelium-dependent vasodilation (EDV) and endothelial-independent vasodilation (EIDV) was evaluated by infusing metacholine and sodium nitroprusside into the brachial artery. Forearm blood flow was measured by venous occlusion plethysmography. The ACE insertion (I)/deletion (D) polymorphism, the T174M and M235T angiotensinogen restriction fragments length polymorphisms, the angiotensin II receptor type 1 (AT1R) A1166C, and the aldosterone synthase gene (CYP11B2) C-344T polymorphisms were analysed.RESULTS: When analysing the ACE, the two angiotensinogen and the aldosterone synthase CYP11B2 genotypes independently, no significant association with endothelial vasodilatory function was found. However, a significant reduction in endothelium-dependent vasodilation was observed in the subjects (n=9) with the ACE D allele and the angiotensinogen T174M genotype (P<0.05). Subjects with the AT1R genotype AC showed a reduction in both EDV (P=0.05) and EIDV (P=0.04) when compared with those with the AA genotype.CONCLUSIONS: The subjects with the ACE D allele in combination with the angiotensinogen T174M genotype are associated with a reduced EDV. This together with the observation that the AC AT1R genotype is associated with a reduction in both EDV and EIDV, supports the hypothesis that endothelial vasodilatory function is influenced by genes in the renin-angiotensinogen system. |
| وصف الملف: | |
| الوصول الحر: | https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-73093Test http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=11380534&dopt=CitationTest |
| قاعدة البيانات: | SwePub |
| تدمد: | 01445979 13652281 |
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| DOI: | 10.1046/j.1365-2281.2001.00336.x |