A Model‐Informed Drug Discovery and Development Strategy for the Novel Glucose‐Responsive Insulin MK‐2640 Enabled Rapid Decision Making
| العنوان: | A Model‐Informed Drug Discovery and Development Strategy for the Novel Glucose‐Responsive Insulin MK‐2640 Enabled Rapid Decision Making |
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| المؤلفون: | Carolyn R. Cho, Bhargava Kandala, Craig Fancourt, Sandra A.G. Visser, Alexander W. Krug |
| المصدر: | Clinical Pharmacology and Therapeutics |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Blood Glucose, medicine.medical_treatment, Decision Making, Computational biology, Models, Biological, 030226 pharmacology & pharmacy, Glucose responsive, 03 medical and health sciences, 0302 clinical medicine, Drug Development, Drug Discovery, Tutorial, Diabetes Mellitus, Animals, Humans, Hypoglycemic Agents, Insulin, Medicine, Computer Simulation, Pharmacology (medical), Pharmacology, Drug discovery, business.industry, Glucose responsiveness, Translational medicine, Clinical trial, Drug development, 030220 oncology & carcinogenesis, business, Non diabetic |
| الوصف: | A model-informed drug discovery and development strategy played a key role in the novel glucose-responsive insulin MK-2640's early clinical development strategy and supported a novel clinical trial paradigm to assess glucose responsiveness. The development and application of in silico modeling approaches by leveraging substantial published clinical insulin pharmacokinetic-pharmacodynamic (PKPD) data and emerging preclinical and clinical data enabled rapid quantitative decision making. Learnings can be applied to define PKPD properties of novel insulins that could become therapeutically meaningful for diabetic patients. |
| تدمد: | 1532-6535 0009-9236 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153380340c63932bd8745f0ccef033beTest https://doi.org/10.1002/cpt.1729Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....153380340c63932bd8745f0ccef033be |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15326535 00099236 |
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