التفاصيل البيبلوغرافية
| العنوان: |
Severe hypoglycemia in users of sulfonylurea antidiabetic agents and antihyperlipidemics. |
| المؤلفون: |
Leonard, CE, Bilker, WB, Brensinger, CM, Han, X, Flory, JH, Flockhart, DA, Gagne, JJ, Cardillo, S, Hennessy, S |
| المصدر: |
Clinical Pharmacology & Therapeutics; May2016, Vol. 99 Issue 5, p538-547, 10p |
| مصطلحات موضوعية: |
HYPOGLYCEMIA, SULFONYLUREAS, HYPOGLYCEMIC agents, DRUG interactions, PUBLIC health, CONFIDENCE intervals, THERAPEUTICS |
| مستخلص: |
Drug-drug interactions causing severe hypoglycemia due to antidiabetic drugs is a major clinical and public health problem. We assessed whether sulfonylurea use with a statin or fibrate was associated with severe hypoglycemia. We conducted cohort studies of users of glyburide, glipizide, and glimepiride plus a statin or fibrate within a Medicaid population. The outcome was a validated, diagnosis-based algorithm for severe hypoglycemia. Among 592,872 persons newly exposed to a sulfonylurea+antihyperlipidemic, the incidence of severe hypoglycemia was 5.8/100 person-years. Adjusted hazard ratios (HRs) for sulfonylurea+statins were consistent with no association. Most overall HRs for sulfonylurea+fibrate were elevated, with sulfonylurea-specific adjusted HRs as large as 1.50 (95% confidence interval (CI): 1.24-1.81) for glyburide+gemfibrozil, 1.37 (95% CI: 1.11-1.69) for glipizide+gemfibrozil, and 1.63 (95% CI: 1.29-2.06) for glimepiride+fenofibrate. Concomitant therapy with a sulfonylurea and fibrate is associated with an often delayed increased rate of severe hypoglycemia. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
