Sporadic and multiple neurofibromas in the head and neck region: a retrospective study of 33 years
| العنوان: | Sporadic and multiple neurofibromas in the head and neck region: a retrospective study of 33 years |
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| المؤلفون: | Raul Negrão Fleury, Cleverson Teixeira Soares, Michele Conceição Pereira, Luciana Sassa Marocchio, Denise Tostes Oliveira |
| المصدر: | Clinical Oral Investigations. 11:165-169 |
| بيانات النشر: | Springer Science and Business Media LLC, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Male, Pathology, medicine.medical_specialty, Neurofibromatosis 1, Skin Neoplasms, Lesion, Plexiform neurofibroma, medicine, Humans, Neurofibroma, Oral mucosa, Neurofibromatosis, Head and neck, General Dentistry, Retrospective Studies, Neurofibroma, Plexiform, business.industry, Mouth Mucosa, Retrospective cohort study, medicine.disease, Nerve sheath tumor, medicine.anatomical_structure, Head and Neck Neoplasms, Female, medicine.symptom, business |
| الوصف: | The neurofibroma occurs as isolated or multiple lesions frequently associated with neurofibromatosis type 1 (NF-1). The aim of this study was to analyze the clinical and histopathological features of neurofibromas, particularly the plexiform variant, in the skin and oral mucosa, discussing their pathogenesis as well as clinical management of isolated lesion unassociated with NF1. The clinicopathologic features of 66 neurofibromas in the head and neck region diagnosed at the pathology laboratories of the Bauru Dentistry School and Lauro de Souza Lima Research Institute from 1970 to 2003 were reviewed. The clinical data, therapy, and follow-up information were obtained from the medical records. The results showed a high frequency of cutaneous lesions (81.8%) occurring mainly in females older than 40 years. Isolated neurofibromas were found in 51.2% of patients, and multiple lesions were often associated with the NF-1. The histopathological analysis demonstrated that diffused neurofibromas occur more frequently than the plexiform type. However, one case of plexiform neurofibroma was detected in the oral mucosa as an isolated lesion non-associated with the NF-1. The indolent clinical behavior of isolated neurofibromas in the head and neck region and the absence of NF-1 association reinforce that sporadic lesion could be hyperplastic or hamartomatous rather than neoplastic in nature. |
| تدمد: | 1436-3771 1432-6981 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::554e3ae6c84517bc24e6cc650d275dd7Test https://doi.org/10.1007/s00784-006-0096-6Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....554e3ae6c84517bc24e6cc650d275dd7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14363771 14326981 |
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