التفاصيل البيبلوغرافية
| العنوان: |
Cytokine biomarkers in tear film for primary open-angle glaucoma. |
| المؤلفون: |
Gupta, Divakar, Wen, Joanne C., Huebner, Janet L., Stinnett, Sandra, Kraus, Virginia B., Tseng, Henry C., Walsh, Molly |
| المصدر: |
Clinical Ophthalmology; Feb2017, Vol. 11, p411-416, 6p |
| مصطلحات موضوعية: |
OPEN-angle glaucoma, PHYSIOLOGICAL effects of cytokines, ENZYME-linked immunosorbent assay, INTRAOCULAR pressure, RETINAL ganglion cells, PHYSIOLOGY, DIAGNOSIS |
| مستخلص: |
Purpose: To determine the utility of tear film cytokines as biomarkers for early primary open-angle glaucoma (POAG). Methods: Patients without POAG and eye drop-naïve patients with newly diagnosed POAG were recruited from an academic hospital-based glaucoma practice. Tear films of recruited patients were obtained and analyzed using a multiplex, high-sensitivity electrochemiluminescent enzyme-linked immunosorbent assay for proinflammatory cytokines (IFNγ, IL-10, IL-12p70, IL-13, IL-1β, IL-2, IL-4, IL-6, IL-8, and TNFα). Results: Mean concentrations of tear film cytokines were lower in the glaucoma group for 8 of 10 cytokines tested. IL-12p70 (3.94±2.19 pg/mL in control vs 2.31±1.156 pg/mL in POAG; P=0.035) was significantly lower in the tear film of patients with newly diagnosed POAG. Conclusion: Proinflammatory cytokines were lower in eye drop-naïve newly diagnosed glaucoma patients. Tear film cytokine profiles may be used as biomarkers of early POAG. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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