التفاصيل البيبلوغرافية
| العنوان: |
Blastoschizomyces capitatus Infection in Patients with Leukemia: Report of 26 Cases. |
| المؤلفون: |
Martino, Rodrigo, Salavert, Miguel, Parody, Rocío, Tomaás, José F., de la Cámara, Rafael, Vázquez, Lourdes, Jarque, Isidro, Prieto, Elena, Sastre, José Luis, Gadea, Ignacio, Pemán, Javier, Sierra, Jorge |
| المصدر: |
Clinical Infectious Diseases; 2/1/2004, Vol. 38 Issue 3, p335-341, 7p |
| مصطلحات موضوعية: |
YEAST fungi, BLASTOMYCETES, MYCOSES, ACUTE leukemia, HEMATOPOIETIC stem cell transplantation, PATIENTS |
| مصطلحات جغرافية: |
SPAIN |
| مستخلص: |
Twenty-six cases of Blastoschizomyces capitatus infection were diagnosed in 25 patients at 7 tertiary care hematology units in Spain over a 10-year period. Most patients (92%) had acute leukemia and developed infection during a period of severe and prolonged neutropenia. Two patients had esophagitis, and the rest had invasive infection. Fungemia (20 cases) was a common finding, with frequent visceral dissemination. The 30-day mortality associated with this infection was 52%, compared with 57% among patients with systemic infection. In a univariate analysis, the following 3 variables had a positive impact on 30-day survival: removal of the central venous catheter within 5 days after the onset of infection (P=.02), a good performance status (P=.003), and receipt of systemic prophylactic or empirical antifungal therapy before infection onset (P=.006). Outcome for neutropenic patients with B. capitatus infection is still poor. Rapid removal of the central venous catheter and novel antifungal therapies are recommended for treatment of this rare infection. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
