التفاصيل البيبلوغرافية
| العنوان: |
Role of Human Immunodeficiency Virus in Influenza- and Respiratory Syncytial Virus–associated Hospitalizations in South African Children, 2011–2016. |
| المؤلفون: |
McMorrow, Meredith L, Tempia, Stefano, Walaza, Sibongile, Treurnicht, Florette K, Moyes, Jocelyn, Cohen, Adam L, Pretorius, Marthi, Hellferscee, Orienka, Wolter, Nicole, Gottberg, Anne von, Nguweneza, Arthemon, McAnerney, Johanna M, Naby, Fathima, Mekgoe, Omphile, Venter, Marietjie, Madhi, Shabir A, Cohen, Cheryl |
| المصدر: |
Clinical Infectious Diseases; 3/1/2019, Vol. 68 Issue 5, p773-780, 8p |
| مصطلحات موضوعية: |
INFLUENZA, HIV infection complications, INFLUENZA epidemiology, HOSPITAL care of children, CONFIDENCE intervals, CROSS infection, MULTIVARIATE analysis, POLYMERASE chain reaction, PUBLIC health surveillance, LOGISTIC regression analysis, RELATIVE medical risk, SEVERITY of illness index, REVERSE transcriptase polymerase chain reaction, RESPIRATORY syncytial virus infections, DISEASE risk factors |
| مصطلحات جغرافية: |
SOUTH Africa |
| مستخلص: |
Background Data describing influenza– or respiratory syncytial virus (RSV)–associated hospitalized illness in children aged <5 years in Africa are limited. Methods During 2011–2016, we conducted surveillance for severe respiratory illness (SRI) in children aged <5 years in 3 South African hospitals. Nasopharyngeal aspirates were tested for influenza and RSV using real-time reverse transcription polymerase chain reaction. We estimated rates of influenza- and RSV-associated hospitalized SRI by human immunodeficiency virus (HIV) status and compared children who tested positive for influenza vs RSV using multivariable penalized logistic regression. Results Among 3650 hospitalized children, 203 (5.6%) tested positive for influenza viruses, 874 (23.9%) for RSV, and 19 (0.5%) for both. The median age of children hospitalized with influenza was 13.9 months vs 4.4 months for RSV (P <.01). Annual influenza-associated hospitalization rates per 100000 were highest among infants aged 6–11 months (545; 95% confidence interval [CI], 409–703), while RSV-associated hospitalization rates were highest in infants aged 0–2 months (6593; 95% CI, 5947–7217). HIV exposure was associated with increased incidence of influenza- and RSV-associated hospitalization in infants aged 0–5 months, with relative risk (RR) 2.2 (95% CI, 1.4–3.4) and 1.4 (95% CI, 1.3–1.6), respectively. HIV infection was associated with increased incidence of influenza- and RSV-associated hospitalization in all age groups; RR 2.7 (95% CI, 2.0–3.5) and 3.8 (95% CI, 3.1–4.8), respectively. Conclusions Influenza- and RSV-associated hospitalizations are common among South African infants. HIV infection and HIV exposure in infants increase risk of influenza- and RSV-associated hospitalization. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
