التفاصيل البيبلوغرافية
| العنوان: |
Is Rifampin Use Associated With Better Outcome in Staphylococcal Prosthetic Valve Endocarditis? A Multicenter Retrospective Study. |
| المؤلفون: |
Bot, Audrey Le, Lecomte, Raphaël, Gazeau, Pierre, Benezit, François, Arvieux, Cédric, Ansart, Séverine, Boutoille, David, Berre, Rozenn Le, Chabanne, Céline, Lesouhaitier, Matthieu, Dejoies, Loren, Flecher, Erwan, Chapplain, Jean-Marc, Tattevin, Pierre, Revest, Matthieu |
| المصدر: |
Clinical Infectious Diseases; 5/1/2021, Vol. 72 Issue 9, pe249-e255, 7p |
| مصطلحات موضوعية: |
RESEARCH, HEART valve diseases, LENGTH of stay in hospitals, CEREBRAL embolism & thrombosis, SCIENTIFIC observation, CONFIDENCE intervals, MULTIVARIATE analysis, MEDICAL cooperation, RETROSPECTIVE studies, TREATMENT duration, INFECTIVE endocarditis, TREATMENT effectiveness, INFECTION, STAPHYLOCOCCAL diseases, DISEASE relapse, STAPHYLOCOCCUS aureus, DESCRIPTIVE statistics, RIFAMPIN, ODDS ratio, COMPLICATIONS of prosthesis, LONGITUDINAL method |
| مستخلص: |
Background International guidelines recommend rifampin-based combinations for staphylococcal prosthetic valve endocarditis (PVE). However, no robust clinical data support this recommendation, and rifampin tolerability is an issue. We aimed to evaluate the impact of rifampin for the treatment of staphylococcal PVE. Methods An observational retrospective cohort study of all adults with staphylococcal PVE (modified Duke criteria) was conducted in 3 referral centers for endocarditis, during years 2000–2018. Primary outcome measurement was 1-year mortality. Results We enrolled 180 patients with PVE due to Staphylococcus aureus (n = 114, 63.3%), or coagulase-negative staphylococci (n = 66, 36.7%), on bioprosthesis (n = 111, 61.7%), mechanical valve (n = 67, 37.2%), or both (n = 2). There were 132 males (73.3%), and mean age was 70.4 ± 12.4 years. Valvular surgery was performed in 51/180 (28.3%) cases. Despite all isolates were susceptible to rifampin, only 101 (56.1%) were treated with rifampin, for a median duration of 33.0 days, whereas 79 (43.9%) received no rifampin. Baseline characteristics were similar in both groups. One-year mortality was, respectively, 37.6% (38/101), and 31.6% (25/79), in patients treated with, or without, rifampin (P =.62). Relapse rates were 5.9% (6/101), and 8.9% (7/79), P =.65. Patients treated with rifampin had longer hospital length-of-stay: 42.3 ± 18.6 vs 31.3 ± 14.0 days (P <.0001). On multivariate analysis, only cerebral emboli (odds ratio [OR] 2.95, 95% confidence interval [CI], 1.30–6.70, P =.009), definite endocarditis (OR 7.15, 95% CI, 1.47–34.77, P =.018), and methicillin-resistant S. aureus (OR 6.04, 95% CI, 1.34–27.26, P =.019), were associated with 1-year mortality. Conclusions A large proportion (43.9%) of staphylococcal PVE received no rifampin. One-year survival and relapse rates were similar in patients treated with or without rifampin. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
