التفاصيل البيبلوغرافية
| العنوان: |
Longitudinal Effect of Antiretroviral Therapy on Markers of Hepatic Toxicity: Impact of Hepatitis C Coinfection. |
| المؤلفون: |
French, Audrey L., Benning, Lorie, Anastos, Kathryn, Augenbraun, Michael, Nowicki, Marek, Sathasivam, Kunthavi, Terrault, Norah A. |
| المصدر: |
Clinical Infectious Diseases; 8/1/2004, Vol. 39 Issue 3, p402-410, 9p |
| مصطلحات موضوعية: |
ANTIRETROVIRAL agents, HIV-positive women, HEPATITIS C virus, HEPATOTOXICOLOGY, AMINOTRANSFERASES, ANTIVIRAL agents |
| مستخلص: |
To characterize longitudinal hepatic toxicity of antiretroviral therapy in HIV-infected women with and without hepatitis C virus (HCV) infection, we measured alanine and aspartate aminotransferase values among women initiating highly active antiretroviral therapy (HAART). For 312 HIV/HCV coinfected women who received HAART for a mean of 108 years, the prevalence of elevated aminotransferase levels >3 times and >5 times the upper limit of normal (ULN) was low (<12% and <4%, respectively), and the prevalence of elevated amino- transferase levels declined over time When we analyzed trends in aminotransferase levels according to type of HAART received among HCV-infected and uninfected women, we found that mean aminotransferase levels declined among 539 women receiving therapy with protease inhibitors (decreases of 5.34%-4.23% of the ULN per year; P values for trend of .007-.06), but mean values among 128 women receiving therapy with non- nucleoside reverse-transcriptase inhibitors remained stable (from decreases of 1.65% to increases of 7.57% of the ULN per year; P values of .19-.71). Our findings lend support to assertions that antiretroviral therapy is safe for women with HCV infection. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
