التفاصيل البيبلوغرافية
| العنوان: |
Advances in Therapy for HIV/Hepatitis C Virus–Coinfected Patients in the Liver Transplant Setting. |
| المؤلفون: |
Campos-Varela, Isabel, Peters, Marion G., Terrault, Norah A. |
| المصدر: |
Clinical Infectious Diseases; Jan2015, Vol. 60 Issue 1, p108-116, 9p |
| مصطلحات موضوعية: |
HEPATITIS C treatment, HIV infections, THERAPEUTICS, LIVER transplantation, DRUG interactions, DISEASE management |
| مستخلص: |
Recent advances in hepatitis C virus (HCV) treatment have the potential to transform the long-term outcomes of HIV/HCV-coinfected patients with liver complications in need of liver transplant or who have undergone prior transplant and are facing graft loss due to recurrent disease.Complications of cirrhosis due to hepatitis C virus (HCV) are increasing, and liver transplantation (LT) is the most effective treatment for those with liver decompensation or small hepatocellular carcinoma. However, for patients with human immunodeficiency virus (HIV) coinfection, barriers to LT exist. This is related to the poorer survival rates post-LT (55% at 5 years) and, up until this year, the limited options for treating those coinfected LT recipients with progressive recurrent HCV disease, the commonest reason for reduced survival. The newly approved antiviral therapies sofosbuvir and simeprevir, with significantly improved efficacy and markedly better safety and tolerability in HIV and transplant patients, offer the opportunity to transform the outcomes of HIV/HCV-coinfected patients with liver complications. Additional new therapies, anticipated within the year, are expected to further simplify the management of coinfected patients in the transplant setting. [ABSTRACT FROM PUBLISHER] |
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| قاعدة البيانات: |
Complementary Index |
