أعرض في EDS

BREG cells in Hashimoto's thyroiditis isolated or associated to further organ-specific autoimmune diseases

التفاصيل البيبلوغرافية
العنوان: BREG cells in Hashimoto's thyroiditis isolated or associated to further organ-specific autoimmune diseases
المؤلفون: Ilaria Stramazzo, Giovanna Romeo, Ilenia Gatto, Giorgio Mangino, Camilla Virili, Alessandro Antonelli, Maria Segni, Marco Centanni, Poupak Fallahi, Maria Giulia Santaguida
المصدر: Clinical Immunology. 184:42-47
بيانات النشر: Elsevier BV, 2017.
سنة النشر: 2017
مصطلحات موضوعية: Male, 0301 basic medicine, Cellular immunity, Thyroiditis, Organ specific, Immunology and Allergy, B-Lymphocytes, Regulatory, B-Lymphocytes, Membrane Glycoproteins, CD19, biology, Tumor Necrosis Factor Receptor Superfamily, Middle Aged, Regulatory, Phenotype, Interleukin-10, Gastritis, Female, Gastritis, Atrophic, Adult, medicine.medical_specialty, Antigens, CD19, Immunology, Vitiligo, Hashimoto Disease, Peripheral blood mononuclear cell, Breg cells, cellular immunity, hashimoto's thyroiditis, polyglandular autoimmune syndrome, thyroid autoimmunity, Autoimmune Diseases, Member 7, 03 medical and health sciences, Hashimoto's thyroiditis, Internal medicine, Hashimoto thyroiditis, Polyglandular autoimmune syndrome, medicine, Humans, In patient, Antigens, Thyroid autoimmunity, Atrophic, business.industry, CD24 Antigen, medicine.disease, ADP-ribosyl Cyclase 1, Tumor Necrosis Factor Receptor Superfamily, Member 7, Celiac Disease, 030104 developmental biology, Endocrinology, Case-Control Studies, Th17 Cells, biology.protein, business
الوصف: Hashimoto thyroiditis (HT) may occur isolated or associated with other non-endocrine autoimmune disorders (NEAD). No data are available about Breg cells in these disorders and this represented the aim of the study. Th17 and Breg cells subset were characterized on peripheral blood mononuclear cells isolated from 18 healthy donors (HD), 19 patients with isolated HT and 26 patients with HT+NEAD. Th17 were higher in patients with isolated HT than in HD but no further changes were seen in patients with HT+NEAD. CD24hiCD38hi unstimulated Breg cells were similar in HT patients and in HD, but significantly higher in patients with HT+NEAD than in both HT and in HD. CD19+CD24hiCD27+ Breg memory phenotype was similar in HD and in HT patients, but decreased in patients with HT+NEAD (23.4%vs38.5%). Upon CpG-stimulation, CD24hiCD38hi IL-10+ Breg cells were higher in HT patients than in HD (3.9%vs1.8%) but similar in patients with HT+NEAD (2.4%).
تدمد: 1521-6616
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68625b9cfcd652274168092bdcee5919Test
https://doi.org/10.1016/j.clim.2017.04.012Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....68625b9cfcd652274168092bdcee5919
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15216616