PReS-endorsed international childhood lupus T2T task force definition of childhood lupus low disease activity state (cLLDAS)
| العنوان: | PReS-endorsed international childhood lupus T2T task force definition of childhood lupus low disease activity state (cLLDAS) |
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| المؤلفون: | Smith, E. M.D., Aggarwal, A., Ainsworth, J., Al-Abadi, E., Avcin, T., Bortey, L., Burnham, J., Ciurtin, C., Hedrich, C. M., Kamphuis, S., Lambert, L., Levy, D. M., Lewandowski, L., Maxwell, N., Morand, E., Ozen, S., Pain, C. E., Ravelli, A., Saad Magalhaes, C., Pilkington, C., Schonenberg-Meinema, D., Scott, C., Tullus, K., Beresford, M. W., Goilav, B., Marks, S., Oni, L. |
| المساهمون: | Paediatric Infectious Diseases / Rheumatology / Immunology, AII - Infectious diseases, AII - Inflammatory diseases, Pediatrics |
| المصدر: | Clinical immunology (Orlando, Fla.), 250:109296. Academic Press Inc. Clinical Immunology, 250:109296. Academic Press |
| بيانات النشر: | Elsevier BV, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | cSLE, cLLDAS, Immunology, Low disease activity, Immunology and Allergy, Childhood-SLE, T2T, Treat-to-target |
| الوصف: | Objective: To achieve a consensus-based definition of Low Disease Activity (LDA) for use in cSLE trials. Methods: The International cSLE T2T Task Force, comprising of paediatric rheumatologists/nephrologists, and adult rheumatologists undertook a series of Delphi surveys/consensus meetings to discuss, refine, and vote upon cSLE LDA criteria. Results: The Task Force agreed that LDA should be based upon the adult-SLE Lupus Low Disease Activity State definition (LLDAS), with modifications to make it applicable to cSLE (cLLDAS). They agreed upon five cLLDAS criteria: (1) SLE Disease Activity Index (SLEDAI)-2 K ≤4, with no activity in major organ systems; (2) no new features of lupus disease activity compared with the last assessment; (3) Physician Global Assessment score of ≤1 (0–3 scale); (4) prednisolone dose of ≤0.15 mg/kg/day, 7.5 mg/day/maximum; while on (5) stable antimalarials, immunosuppressives, and biologics. Conclusions: A cSLE-appropriate definition of cLLDAS has been generated, maintaining alignment with the adult-SLE definition to promote life-course research. |
| تدمد: | 1521-6616 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f68498ebe651a4a5a15b970a534432bTest https://doi.org/10.1016/j.clim.2023.109296Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....4f68498ebe651a4a5a15b970a534432b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15216616 |
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