This study aims to identify multidetector row CT (MDCT) findings that differentiate paraduodenal pancreatitis (PDP) from groove carcinomas (GC).Two radiologists retrospectively reviewed various imaging features on pancreas protocol CT scans of 8 PDP and 8 GC patients. Two-tailed Fisher's Exact Test was used for statistical analysis.MDCT findings correlating with PDP included benign common bile duct morphology (P.01), duodenal wall thickening (P.05), and cystic groove lesions (P.01). A statistical difference in gastroduodenal artery (GDA) encasement was not observed (P=.119).There are several MDCT findings that favor PDP over GC. However, presence of GDA encasement is not a reliable distinguishing feature.