Apolipoprotein B gene DNA polymorphisms are associated with macro- and microangiopathy in non-insulin-dependent diabetes mellitus
| العنوان: | Apolipoprotein B gene DNA polymorphisms are associated with macro- and microangiopathy in non-insulin-dependent diabetes mellitus |
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| المؤلفون: | Kai von Dickhoff, Y. Antero Kesäniemi, Pasi I. Salmela, Markku J. Savolainen, Olavi Ukkola |
| المصدر: | Clinical Genetics. 44:177-184 |
| بيانات النشر: | Wiley, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Male, Apolipoprotein E, medicine.medical_specialty, Apolipoprotein B, Coronary Disease, Locus (genetics), chemistry.chemical_compound, Apolipoproteins E, Retinal Diseases, Internal medicine, Diabetes mellitus, Genetics, medicine, Humans, Allele, Genetics (clinical), Apolipoproteins B, Polymorphism, Genetic, biology, Cholesterol, Microangiopathy, DNA, Middle Aged, medicine.disease, Endocrinology, Diabetes Mellitus, Type 2, chemistry, biology.protein, Female, Restriction fragment length polymorphism |
| الوصف: | Ukkola O, Savolainen MJ, Salmela PI, von Dickhoff K, Kesaniemi YA. Apolipoprotein B gene DNA polymorphisms are associated with macro-and microangiopathy in non-insulin-dependent diabetes mellitus. Clin Genet 1993: 44: 177–184. © Munksgaard, 1993 The relationship between diabetic macroangiopathy or microangiopathy and apolipoprotein B (apoB) polymorphism was studied in 139 male and 129 female patients with non-insulin-dependent diabetes (NIDDM) mellitus, comprising consecutive patients with poor diabetic control (HBA1 13.2%\pm2.7 (SD)) referred to our hospital. Plasma cholesterol and triglyceride concentrations were higher in the patients who were homozygous for the X2 allele (presence of Xba I cleavage site). Patients with the X1 allele (absence of Xba I cleavage site) tended to have a higher frequency of macroangiopathy, although the differences were not statistically significant. There was no difference in the prevalence of microangiopathy between the groups. In subjects with only an R1 allele (= R +; homozygous for the presence of EcoR I cleavage site) the prevalence of coronary heart disease (CHD) was observed to be high (61.9%) as compared to the subjects possessing an R2 allele (= R —; homozygous or heterozygous for the absence of the EcoR I cleavage site) (46.7%; p |
| تدمد: | 1399-0004 0009-9163 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2997ceb39d377dfc4ba8b6adc87e8343Test https://doi.org/10.1111/j.1399-0004.1993.tb03875.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....2997ceb39d377dfc4ba8b6adc87e8343 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13990004 00099163 |
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