التفاصيل البيبلوغرافية
العنوان:
Association Between a Polymorphism in Cannabinoid Receptor 2 and Severe Necroinflammation in Patients With Chronic Hepatitis C
المؤلفون:
Mariantonietta Pisaturo , Margherita Macera , Giulia Bellini , Aldo Marrone , Rosa Zampino , Luigi Elio Adinolfi , Emanuele Miraglia del Giudice , Laura Perrone , Evangelista Sagnelli , Giuseppe Pasquale , Nicola Coppola , Adriana Boemio , Bruno Nobili , Sabatino Maione , Francesca Rossi
المساهمون:
Coppola, N., Zampino, R., Bellini, G., Macera, M., Marrone, A., Pisaturo, M., Boemio, A., Nobili, B., Pasquale, G., Maione, S., Adinolfi, L. E., Perrone, L., Sagnelli, E., Miraglia Del Giudice, E., Rossi, F.
المصدر:
Clinical Gastroenterology and Hepatology . 12:334-340
بيانات النشر:
Elsevier BV, 2014.
سنة النشر:
2014
مصطلحات موضوعية:
Male , medicine.medical_specialty , Cannabinoid receptor , Cannabinoid system , Logistic Model , Hepatitis C virus , Mutation, Missense , SNP , medicine.disease_cause , Polymorphism, Single Nucleotide , Gastroenterology , Asymptomatic , Receptor, Cannabinoid, CB2 , Liver disease , Genetic , Internal medicine , Genotype , medicine , Cannabinoid receptor type 2 , Humans , Asymptomatic Disease , Hepatology , medicine.diagnostic_test , business.industry , Hepatitis C, Chronic , Middle Aged , Viral Load , medicine.disease , Virology , Logistic Models , Liver , Liver biopsy , Asymptomatic Diseases , Disease Progression , Female , lipids (amino acids, peptides, and proteins) , Steatosis , medicine.symptom , business , Human
الوصف:
Background & Aims: The cannabinoid receptor 2 (CB2) has been implicated in liver disease. The single-nucleotide polymorphism rs35761398 in cannabinoid receptor 2 gene (CNR2), which encodes the CB2, substitutes glutamine (Q) 63 with arginine (R), and reduces the function of the gene product. We investigated the effects of CNR2 rs35761398 in patients with hepatitis C virus (HCV) infection. Methods: We studied 169 consecutive patients with asymptomatic chronic hepatitis (tested positive for anti-HCV and HCV RNA) at 2 liver units in southern Italy. First, liver biopsy samples were collected from July 2009 through December 2011. All patients were naive to antiviral therapy; CNR2 genotype was determined by polymerase chain reaction analysis. Results: Patients with the CB2-63 QQ variant had higher serum levels of aminotransferase than those with the CB2-63 QR or RR variants; they also had higher histologic activity index (HAI) scores (8.6 ± 3.8) than patients without the CB2-63 RR variant (5.3 ± 3.6; P < .005) or those with the CB2-63 QR variant (5.8 ± 3.3; P < .001). Patients with the different variants of CNR2 did not differ in fibrosis stage or steatosis score. Moderate or severe chronic hepatitis (HAI score, >8) was identified more frequently (55.5%) in patients with the CB2-63 QQ variant than in those with the 63 QR (20%; P < .005) or RR variants (17.4%; P < .005). In logistic regression analysis, the CB2-63 QQ variant and fibrosis score were independent predictors of moderate or severe chronic hepatitis (HAI score, >8; P < .0001). Conclusions: The CB2-63 QQ variant of CNR2 is associated with more severe inflammation and hepatocellular necrosis in patients with HCV infection. © 2014 AGA Institute.
تدمد:
1542-3565
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18febd9b6f739b50f5a71bba20c9df51Test https://doi.org/10.1016/j.cgh.2013.05.008Test
حقوق:
CLOSED
رقم الانضمام:
edsair.doi.dedup.....18febd9b6f739b50f5a71bba20c9df51
قاعدة البيانات:
OpenAIRE
