Investigation into the mechanisms by which nedocromil sodium, frusemide and bumetanide inhibit the histamine-induced itch and flare response in human skin in vivo
| العنوان: | Investigation into the mechanisms by which nedocromil sodium, frusemide and bumetanide inhibit the histamine-induced itch and flare response in human skin in vivo |
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| المؤلفون: | Geraldine F. Clough, E. F. Willis, M. K. Church |
| المصدر: | Clinical Experimental Allergy. 34:450-455 |
| بيانات النشر: | Wiley, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Adult, Nedocromil, Urticaria, Sodium, Immunology, chemistry.chemical_element, Pharmacology, Histamine receptor, chemistry.chemical_compound, Ganglia, Sensory, Furosemide, Laser-Doppler Flowmetry, medicine, Humans, Immunology and Allergy, Single-Blind Method, Nedocromil Sodium, skin and connective tissue diseases, Bumetanide, Skin, Iontophoresis, business.industry, Vasodilation, medicine.anatomical_structure, chemistry, Histamine H1 Antagonists, business, Histamine, medicine.drug, Sensory nerve |
| الوصف: | Summary Background In a previous study, iontophoresis of nedocromil sodium into human skin in vivo was shown to reduce histamine-induced itch and flare. In asthma, the Na+/K+/2Cl− cotransporter inhibitors, frusemide and bumetanide, have been reported to have many similar actions to nedocromil sodium. Objective To compare the effects of these drugs in the histamine-induced itch, flare and weal response in human skin in vivo and elucidate their site of action. Methods Nedocromil sodium, frusemide bumetanide and reversed osmosis water (control), were introduced by iontophoresis into the forearm skin of 10 volunteers in each of two single-blind studies. In study 1, histamine (20 μL of 100 μm) or vehicle was injected into the area of iontophoresis 10 min later. In study 2, histamine or vehicle was injected 5 mm outside the area of iontophoresis so the flare developed over the area of iontophoresis. Itch was scored on a visual analogue scale every 20 s for 5 min, flare areas were assessed using scanning laser Doppler imaging up to 10 min and weal was assessed by planimetry at 10 min. Results In study 1, nedocromil sodium, frusemide and bumetanide reduced itch scores by 36%, 48% and 34%, respectively, and flare areas by 17%, 26% and 15% respectively (all P |
| تدمد: | 1365-2222 0954-7894 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e881dcad0dd5da834b5936b008b4f4f2Test https://doi.org/10.1111/j.1365-2222.2004.01898.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....e881dcad0dd5da834b5936b008b4f4f2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652222 09547894 |
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