Association of cardiovascular health and epigenetic age acceleration
| العنوان: | Association of cardiovascular health and epigenetic age acceleration |
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| المؤلفون: | Matthew A. Allison, Aladdin H. Shadyab, Wei Zhang, Philip Greenland, Hilary A. Tindle, Gretchen L. Wells, Sadiya S. Khan, Donald M. Lloyd-Jones, Rami Nassir, Lisa W. Martin, Andrea A. Baccarelli, Lifang Hou, Eric A. Whitsel, JoAnn E. Manson, Yinan Zheng, Tess D. Pottinger |
| المصدر: | Clinical Epigenetics Clinical epigenetics, vol 13, iss 1 |
| بيانات النشر: | BioMed Central, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Aging, Younger age, Health Status, Women’s health initiative (WHI), Disease, 030204 cardiovascular system & hematology, Cardiovascular, Epigenesis, Genetic, Cohort Studies, 0302 clinical medicine, Genetics (clinical), media_common, Cause of death, DNA methylation, Women's health initiative, Women's Health Initiative, Longevity, Simple seven, American Heart Association, Middle Aged, Postmenopause, Cardiovascular Diseases, Cohort, Female, medicine.medical_specialty, Cardiovascular health (CVH), media_common.quotation_subject, Cardiovascular health, Clinical Sciences, Epigenetic age acceleration, Acceleration, Paediatrics and Reproductive Medicine, 03 medical and health sciences, Genetic, Internal medicine, Genetics, medicine, Humans, Epigenetics, Molecular Biology, Aged, business.industry, Research, United States, Good Health and Well Being, 030104 developmental biology, Cross-Sectional Studies, Women's Health, Women’s health initiative, CpG Islands, business, Epigenesis, Developmental Biology |
| الوصف: | Background Cardiovascular health (CVH) has been defined by the American Heart Association (AHA) as the presence of the “Life’s Simple 7” ideal lifestyle and clinical factors. CVH is known to predict longevity and freedom from cardiovascular disease, the leading cause of death for women in the United States. DNA methylation markers of aging have been aggregated into a composite epigenetic age score, which is associated with cardiovascular morbidity and mortality. However, it is unknown whether poor CVH is associated with acceleration of aging as measured by DNA methylation markers in epigenetic age. Methods and results We performed a cross-sectional analysis of racially/ethnically diverse post-menopausal women enrolled in the Women’s Health Initiative cohort recruited between 1993 and 1998. Epigenetic age acceleration (EAA) was calculated using DNA methylation data on a subset of participants and the published Horvath and Hannum methods for intrinsic and extrinsic EAA. CVH was calculated using the AHA measures of CVH contributing to a 7-point score. We examined the association between CVH score and EAA using linear regression modeling adjusting for self-reported race/ethnicity and education. Among the 2,170 participants analyzed, 50% were white and mean age was 64 (7 SD) years. Higher or more favorable CVH scores were associated with lower extrinsic EAA (~ 6 months younger age per 1 point higher CVH score, p p Conclusions These cross-sectional observations suggest a possible mechanism by which ideal CVH is associated with greater longevity. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1868-7083 1868-7075 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368f5df9476ab13f8130d5656d65d54fTest http://europepmc.org/articles/PMC7905851Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....368f5df9476ab13f8130d5656d65d54f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18687083 18687075 |
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