Decreased physical activity, reduced QoL and presence of debilitating fatigue in patients with Addison's disease
| العنوان: | Decreased physical activity, reduced QoL and presence of debilitating fatigue in patients with Addison's disease |
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| المؤلفون: | Marieke de Vries, Janine H. Stubbe, Lisanne C C J Smans, Ad R. M. M. Hermus, H. Hofstetter, Pierre M. J. Zelissen, Frank J G Backx, Eline S. van der Valk |
| المساهمون: | Kenniscentrum Bewegen, Sport en Voeding |
| المصدر: | Clinical endocrinology, 85(3), 354-60. Wiley-Blackwell Clinical Endocrinology, 3, 85, 354-360 Clinical Endocrinology, 85, 3, pp. 354-60 Clinical Endocrinology, 85(3), 354. Wiley-Blackwell Clinical Endocrinology, 85, 354-60 |
| بيانات النشر: | Wiley, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, Hydrocortisone, Cross-sectional study, Endocrinology, Diabetes and Metabolism, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Comorbidity, 0302 clinical medicine, Endocrinology, Musculoskeletal disease, Life, Quality of life, CH - Child Health, Surveys and Questionnaires, 030212 general & internal medicine, Young adult, Fatigue, Netherlands, Aged, 80 and over, Medicine(all), Educational status, Age Factors, Addison disease, Middle Aged, humanities, Diabetes and Metabolism, Multicenter Study, Health, Fludrocortisone, Addison's disease, Hypertension, Female, Healthy Living, Human, medicine.drug, Adult, medicine.medical_specialty, Adolescent, Hormone Replacement Therapy, Hypercholesterolemia, 030209 endocrinology & metabolism, Major clinical study, Dutchman, Multiple sclerosis, Young Adult, 03 medical and health sciences, Sex Factors, Cerebrovascular accident, Internal medicine, Journal Article, Adrenal insufficiency, medicine, Chronic fatigue syndrome, Humans, Exercise, Glucocorticoids, Disease severity, Prasterone, Aged, Physical activity, business.industry, Mental disease, medicine.disease, Corticosteroid therapy, Cross-Sectional Studies, Short Form 36, Cortisone acetate, Lung disease, ELSS - Earth, Life and Social Sciences, Healthy for Life, business, Controlled study |
| الوصف: | Background: Health-related quality of life in patients with Addison's disease has been assessed in various European countries, indicating a reduced quality of life. However, no studies have addressed the impact of Addison's disease on physical activity. Objective: The aim of this study was to investigate the quality of life in Dutch patients with Addison's disease particularly regarding the presence of fatigue and the ability to be physically active. Methods: In this cross-sectional study, a postal survey was performed among Dutch patients with Addison's disease on stable glucocorticoid replacement therapy with hydrocortisone or cortisone acetate. For quality of life and physical activity assessment, patients completed general and health-related quality of life and physical activity questionnaires, and scores were compared to Dutch controls. Results: A total of 328 patients with Addison's disease were studied. In patients with Addison's disease, only 45·7% met the standard of physical activity (Combinorm) compared to 67·8% of Dutch controls (P < 0·01). Forty-eight per cent of patients showed abnormal fatigue, while 61% had severe fatigue. The CIS fatigue scores were significantly higher compared to controls (P < 0·01). We found reduced general subjective health-related QoL scores in both male and female patients, especially in younger patients |
| وصف الملف: | image/pdf; application/pdf |
| تدمد: | 0300-0664 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::871ce48a74d95368253a8103cfadf610Test https://doi.org/10.1111/cen.13059Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....871ce48a74d95368253a8103cfadf610 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03000664 |
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