Personalized laboratory medicine: a patient-centered future approach
| العنوان: | Personalized laboratory medicine: a patient-centered future approach |
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| المؤلفون: | Lisa Simi, Helena Podgornik, Pieter Vermeersch, Irene Mancini, Ivan Brandslund, Barbka Repic Lampret, Matthias Schwab, Mario Pazzagli, Ron H.N. van Schaik, Irena Prodan Žitnik, Katarina Trebušak Podkrajšek, Janja Marc, Csilla Sipeky, Chiara Di Resta, Darko Cerne |
| المساهمون: | Žitnik, Irena Prodan, Zerne, Darko, Mancini, Irene, Simi, Lisa, Pazzagli, Mario, Di Resta, Chiara, Podgornik, Helena, Lampret, Barbka Repi, Podkrajšek, Katarina Trebušak, Sipeky, Csilla, Van Schaik, Ron, Brandslund, Ivan, Vermeersch, Pieter, Schwab, Matthia, Marc, Janja, Clinical Chemistry |
| المصدر: | Prodan Žitnik, I, Černe, D, Mancini, I, Simi, L, Pazzagli, M, Di Resta, C, Podgornik, H, Repič Lampret, B, Trebušak Podkrajšek, K, Sipeky, C, Van Schaik, R, Brandslund, I, Vermeersch, P, Schwab, M & Marc, J 2018, ' Personalized laboratory medicine : A patient-centered future approach ', Clinical Chemistry and Laboratory Medicine, vol. 56, no. 12, pp. 1981–1991 . https://doi.org/10.1515/cclm-2018-0181Test Clinical Chemistry and Laboratory Medicine (CCLM) Clinical Chemistry and Laboratory Medicine, 56(12), 1981-1991. De Gruyter |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Cost effectiveness, Process (engineering), molecular profiling, proteome, Clinical Biochemistry, Population, Medical laboratory, MINIMAL RESIDUAL DISEASE, Disease, ACUTE MYELOID-LEUKEMIA, 03 medical and health sciences, advanced omics technologie, PRECISION MEDICINE, SAFER, Patient-Centered Care, medicine, Medical Laboratory Science, Humans, OMIC TECHNOLOGIES, Medical physics, Precision Medicine, education, genome, advanced omics technologies, education.field_of_study, Science & Technology, HYPERTROPHIC CARDIOMYOPATHY, business.industry, diagnostic marker, Biochemistry (medical), ADVERSE DRUG-REACTIONS, General Medicine, MASS-SPECTROMETRY, BIOMARKER DISCOVERY, 3. Good health, THIOPURINE METHYLTRANSFERASE GENOTYPE, Medical Laboratory Technology, 030104 developmental biology, IMPLEMENTATION CONSORTIUM GUIDELINES, metabolome, Personalized medicine, Biostatistics, business, Life Sciences & Biomedicine, transcriptome |
| الوصف: | In contrast to population-based medical decision making, which emphasizes the use of evidence-based treatment strategies for groups of patients, personalized medicine is based on optimizing treatment at the level of the individual patient. The creation of molecular profiles of individual patients was made possible by the advent of "omics" technologies, based on high throughput instrumental techniques in combination with biostatistics tools and artificial intelligence. The goal of personalized laboratory medicine is to use advanced technologies in the process of preventive, curative or palliative patient management. Personalized medicine does not rely on changes in concentration of a single molecular marker to make a therapeutic decision, but rather on changes of a profile of markers characterizing an individual patient's status, taking into account not only the expected response to treatment of the disease but also the expected response of the patient. Such medical approach promises a more effective diagnostics with more effective and safer treatment, as well as faster recovery and restoration of health and improved cost effectiveness. The laboratory medicine profession is aware of its key role in personalized medicine, but to empower the laboratories, at least an enhancement in cooperation between disciplines within laboratory medicine will be necessary. ispartof: CLINICAL CHEMISTRY AND LABORATORY MEDICINE vol:56 issue:12 pages:1981-1991 ispartof: location:Germany status: published |
| وصف الملف: | Print; application/pdf |
| اللغة: | English |
| تدمد: | 1437-4331 1434-6621 |
| DOI: | 10.1515/cclm-2018-0181 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bdae67c3df2d53c75a233945c14b782Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3bdae67c3df2d53c75a233945c14b782 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14374331 14346621 |
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| DOI: | 10.1515/cclm-2018-0181 |