Microalbuminuria in Diabetic Patients: Relationship to Lipid, Glyco-metabolic, Coagulation and Fibrinolysis Parameters
| العنوان: | Microalbuminuria in Diabetic Patients: Relationship to Lipid, Glyco-metabolic, Coagulation and Fibrinolysis Parameters |
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| المؤلفون: | S. H. J. Donders, J. W. J. van Wersch, L.W.J.J.M. Westerhuis, W.J.R.R. Venekamp |
| المصدر: | Clinical Chemistry and Laboratory Medicine. 29:493-498 |
| بيانات النشر: | Walter de Gruyter GmbH, 1991. |
| سنة النشر: | 1991 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, endocrine system diseases, Lipoproteins, medicine.medical_treatment, education, Clinical Biochemistry, Diabetic angiopathy, urologic and male genital diseases, Fibrinogen, chemistry.chemical_compound, Predictive Value of Tests, Internal medicine, Diabetes mellitus, Fibrinolysis, medicine, Albuminuria, Humans, Diabetic Nephropathies, Blood Coagulation, Aged, Aged, 80 and over, Glycated Hemoglobin, business.industry, Insulin, Biochemistry (medical), nutritional and metabolic diseases, General Medicine, Middle Aged, medicine.disease, female genital diseases and pregnancy complications, Cholesterol, Diabetes Mellitus, Type 1, Fructosamine, Endocrinology, chemistry, Female, lipids (amino acids, peptides, and proteins), Microalbuminuria, medicine.symptom, business, Diabetic Angiopathies, medicine.drug |
| الوصف: | One hundred and sixteen insulin treated diabetic patients were evaluated for the relationship between the presence of microalbuminuria and several lipid, glyco-metabolic, coagulation and fibrinolysis factors. A significant correlation existed only between microalbuminuria and HbA1c (r = 0.23, p = 0.008) and D-dimer (r = 0.28, p = 0.002). After the subdivision of the patients in a group without (n = 85) and a group with microalbuminuria (n = 31) significant differences were found between these two groups for the HDL-cholesterol content (p less than 0.05), the HbA1c level (p less than 0.01) and for the D-dimer concentration (p less than 0.01). Comparison of the patient groups without and with microalbuminuria separately with a healthy volunteers group without albuminuria resulted in significant differences for HDL-cholesterol, triacylglycerols, HbA1c, fructosamine, fibrin monomer and D-dimer, whereas fibrinogen also was significantly different between the diabetic group without microalbuminuria and the healthy volunteers group. Several factors predisposing for atherosclerosis (decrease of HDL-cholesterol, increase of triacylglycerols, coagulation activation with relatively insufficient fibrinolysis) were noticed in both diabetic groups without or with microalbuminuria, but more pronounced in the latter group. The appliance of a Receiver Operating Characteristic (ROC) curve for HbA1c against microalbuminuria (cut-off level 20 micrograms/min) reconfirmed the value of adequate glycaemic control in diabetics for the prevention of microalbuminuria. In conclusion the results of this study show a significantly poorer glycaemic control in insulin treated diabetics with microalbuminuria than in those without microalbuminuria. The presence of lower HDL-cholesterol, higher triacylglycerols and the elevation of fibrin monomers and D-dimers is more pronounced in the microalbuminuria group.(ABSTRACT TRUNCATED AT 250 WORDS) |
| وصف الملف: | application/pdf |
| تدمد: | 1437-4331 1434-6621 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe52e3f4eaa848963b217b9818ca6127Test https://doi.org/10.1515/cclm.1991.29.8.493Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fe52e3f4eaa848963b217b9818ca6127 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14374331 14346621 |
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