Association of Inflammation-Related and microRNA Gene Expression with Cancer-Specific Mortality of Colon Adenocarcinoma
| العنوان: | Association of Inflammation-Related and microRNA Gene Expression with Cancer-Specific Mortality of Colon Adenocarcinoma |
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| المؤلفون: | Siu Tsan Yuen, Carlo M. Croce, Elise D. Bowman, Suet Yi Leung, Aaron J. Schetter, Giang Nguyen, Curtis C. Harris, Jason E. Hawkes, Ewy Mathé |
| المصدر: | Clinical Cancer Research. 15:5878-5887 |
| بيانات النشر: | American Association for Cancer Research (AACR), 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Male, Oncology, Cancer Research, medicine.medical_specialty, Colorectal cancer, MicroRNA Gene, Adenocarcinoma, Article, Cohort Studies, Risk Factors, Internal medicine, microRNA, Biomarkers, Tumor, medicine, Humans, Gene silencing, MicroRNAs - genetics, Survival rate, Aged, Aged, 80 and over, Inflammation, Reverse Transcriptase Polymerase Chain Reaction, business.industry, Gene Expression Profiling, Cancer, Colonic Neoplasms - diagnosis - genetics - mortality, Middle Aged, Prognosis, medicine.disease, Survival Rate, Gene expression profiling, MicroRNAs, Colonic Neoplasms, Immunology, Cytokines, Adenocarcinoma - diagnosis - genetics - mortality, Inflammation - genetics, Tumor Markers, Biological - genetics, Female, business |
| الوصف: | Purpose: Inflammatory genes and microRNAs have roles in colon carcinogenesis; therefore, they may provide useful biomarkers for colon cancer. This study examines the potential clinical utility of an inflammatory gene expression signature as a prognostic biomarker for colon cancer in addition to previously examined miR-21 expression. Experimental Design: Quantitative reverse transcriptase-PCR. was used to measure the expression of 23 inflammatory genes in colon adenocarcinomas and adjacent noncancerous tissues from 196 patients. These data were used to develop models for cancer-specific mortality on a training cohort (n = 57), and this model was tested in both a test (n = 56) and a validation (n = 83) cohort. Expression data for miR-21 were available for these patients and were compared and combined with inflammatory gene expression. Results: PRG1, IL-10, CD68, IL-23a, and IL-12a expression in noncancerous tissue, and PRG1, ANXA1, IL-23a, IL-17a, FOXP3, and HLA-DRA expression in tumor tissues were associated with poor prognosis based on Cox regression (|Z-score| >1.5) and were used to generate the inflammatory risk score (IRS). IRS was associated with cancer-specific mortality in the training, test (P = 0.01), and validation (P = 0.02) cohorts. This association was strong for stage II cases (P = 0.002). Expression of miR-21 was associated with IL-6, IL-8, IL-10, IL-12a, and NOS2a, providing evidence that the function of this micro-RNA and these inflammatory genes are linked. Both IRS and miR-21 expression were independently associated with cancer-specific mortality, including stage II patients alone. Conclusion: IRS and miR-21 expression are independent predictors of colon cancer prognosis and may provide a clinically useful tool to identify high-risk patients. © 2009 American Association for Cancer Research. link_to_OA_fulltext |
| تدمد: | 1557-3265 1078-0432 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd601de8f325c7153a8098644df1cdbcTest https://doi.org/10.1158/1078-0432.ccr-09-0627Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dd601de8f325c7153a8098644df1cdbc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15573265 10780432 |
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