دورية أكاديمية
Predicting Survival in Patients Undergoing Resection for Locally Recurrent Retroperitoneal Sarcoma: A Study and Novel Nomogram from TARPSWG
| العنوان: | Predicting Survival in Patients Undergoing Resection for Locally Recurrent Retroperitoneal Sarcoma: A Study and Novel Nomogram from TARPSWG |
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| المؤلفون: | Raut, C.P., Callegaro, D., Miceli, R., Barretta, F., Rutkowski, P., Blay, J.Y., Lahat, G., Strausss, D.C., Gonzalez, R., Ahuja, N., Grignani, G., Quagliuolo, V., Stoeckle, E., Paoli, A. de, Pillarisetty, V.G., Nessim, C., Swallow, C.J., Bagaria, S., Canter, R., Mullen, J., Gelderblom, H.J., Pennacchioli, E., Coevorden, F. van, Cardona, K., Fiore, M., Fairweather, M., Gronchi, A. |
| المصدر: | Clinical Cancer Research |
| سنة النشر: | 2019 |
| المجموعة: | Leiden Repository (Leiden University) |
| الوصف: | Purpose: The role of surgery for first relapse locally recurrent retroperitoneal sarcoma (RPS-LR1) is uncertain. We report outcomes of the largest RPS-LR1 series and propose a new prognostic nomogram.Experimental Design: Patients with consecutive RPS-LR1 without distant metastases who underwent resection at 22 centers (2002-2011) were included. Endpoints were disease-free and overall survival (DFS, OS) and crude-cumulative-incidence (CCI) of local/distant recurrence from second surgery. Nomograms predicting DFS and OS from second surgery were developed and validated (calibration plots); discrimination was assessed (Harrell C index).Results: Of 684 patients identified, full prognostic variable data were available for 602. Initial surgery for primary RPS was performed at our institutions in 188 patients (31%) and elsewhere in 414 (69%). At a median follow-up of 119 months [Interquartile range (IQR), 80-169] from initial surgery and 75 months (IQR 50-105) from second surgery, 6-year DFS and OS were 19.2% [95% confidence interval (CI), 16.0-23.0%] and 54.1% (95% CI, 49.8-58.8%), respectively. Recurrence patterns and survival probability were histology-specific, with liposarcoma subtypes having the highest 6-year CCI of second local recurrence (LR, 60.2%-70.9%) and leiomyosarcoma (LMS) having higher 6-year CCI of distant metastasis (DM, 36.3%). Nomograms included age at second surgery, multifocality, grade, completeness of second surgery, histology, chemotherapy/radiotherapy at first surgery, and number of organs resected at first surgery. OS and DFS nomograms showed good calibration and discriminative ability (C index 0.70 and 0.67, respectively).Conclusions: We developed nomograms to predict DFS and OS for patients undergoing RPS-LR1 resection. Nomograms provide individualized, disease-relevant estimations of survival for RPS-LR1 patients and assist in clinical decisions. ; Experimentele farmacotherapie |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | lumc-id: 84212064; https://hdl.handle.net/1887/122790Test |
| DOI: | 10.1158/1078-0432.CCR-18-2700 |
| الإتاحة: | https://doi.org/10.1158/1078-0432.CCR-18-2700Test https://hdl.handle.net/1887/122790Test |
| رقم الانضمام: | edsbas.1D67A442 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1158/1078-0432.CCR-18-2700 |
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