نتائج البحث

1

Potent Activity of an Anti-ICAM1 Antibody–Drug Conjugate against Multiple Myeloma

المؤلفون: Daniel W. Sherbenou, Thomas G. Martin, Olivia Perez De Acha, Byron Hann, Blake T. Aftab, Megan Murnane, Yang Su, Jeffery L. Wolf, Shelby C. Bearrows, Bin Liu, Christopher R. Behrens

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research, vol 26, iss 22
Clin Cancer Res

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Immunoconjugates, medicine.medical_treatment, Mice, 0302 clinical medicine, hemic and lymphatic diseases, Monoclonal, Multiple myeloma, Cancer, Tumor, Antibodies, Monoclonal, Hematology, Middle Aged, Intercellular Adhesion Molecule-1, Flow Cytometry, Antibodies, Anti-Idiotypic, Anti-Idiotypic, medicine.anatomical_structure, Oncology, 5.1 Pharmaceuticals, 030220 oncology & carcinogenesis, Heterografts, Female, Development of treatments and therapeutic interventions, Multiple Myeloma, Biotechnology, Adult, Antibody-drug conjugate, medicine.drug_class, Oncology and Carcinogenesis, Monoclonal antibody, Article, Antibodies, Cell Line, 03 medical and health sciences, Rare Diseases, Clinical Research, In vivo, Cell Line, Tumor, medicine, Animals, Humans, Oncology & Carcinogenesis, Cell Proliferation, Aged, business.industry, Daratumumab, Immunotherapy, medicine.disease, ADP-ribosyl Cyclase 1, Orphan Drug, 030104 developmental biology, Cancer research, Bone marrow, business, Ex vivo

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c90915ca7c606383916fa2bf8e189cbTest
https://doi.org/10.1158/1078-0432.ccr-20-0400Test

2

Changes in Peripheral and Local Tumor Immunity after Neoadjuvant Chemotherapy Reshape Clinical Outcomes in Patients with Breast Cancer

المصدر: Clin Cancer Res

مصطلحات موضوعية: Adult, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Paclitaxel, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Triple Negative Breast Neoplasms, Disease, CD8-Positive T-Lymphocytes, Article, B7-H1 Antigen, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, 0302 clinical medicine, Breast cancer, Albumins, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Tumor Microenvironment, medicine, Humans, Aged, Chemotherapy, business.industry, Immunotherapy, Middle Aged, Gene signature, Prognosis, medicine.disease, Neoadjuvant Therapy, Progression-Free Survival, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, Treatment Outcome, 030104 developmental biology, 030220 oncology & carcinogenesis, Biomarker (medicine), Female, Cytokine secretion, Neoplasm Recurrence, Local, business, CD8

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bcb791e74b1e7256046bab4264aacd2Test
https://doi.org/10.1158/1078-0432.ccr-19-3685Test

3

PD-L1 Protein Expression on Both Tumor Cells and Macrophages are Associated with Response to Neoadjuvant Durvalumab with Chemotherapy in Triple-negative Breast Cancer

المؤلفون: Kim Blenman, Fahad Shabbir Ahmed, Patricia Gaule, John J. McGuire, David L. Rimm, Lajos Pusztai, Katir K Patel

المصدر: Clin Cancer Res

مصطلحات موضوعية: Adult, 0301 basic medicine, Cancer Research, Durvalumab, Stromal cell, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Antigens, Differentiation, Myelomonocytic, Triple Negative Breast Neoplasms, B7-H1 Antigen, Article, 03 medical and health sciences, Cytokeratin, Lymphocytes, Tumor-Infiltrating, 0302 clinical medicine, Breast cancer, Immune system, Stroma, Antigens, CD, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, medicine, Humans, Triple-negative breast cancer, Aged, Cell Proliferation, business.industry, Macrophages, Antibodies, Monoclonal, Immunotherapy, Middle Aged, medicine.disease, Neoadjuvant Therapy, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer research, Female, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333ffa2e1b4380d458c294bb606f3a2bTest
https://doi.org/10.1158/1078-0432.ccr-20-1303Test

4

Talimogene Laherparepvec and Pembrolizumab in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (MASTERKEY-232): A Multicenter, Phase 1b Study

المؤلفون: Burak Gumuscu, Kevin J. Harrington, Hoi-Shen Radcliffe, Lillian L. Siu, Wendy Snyder, Danny Rischin, Beatriz Castelo Fernandez, Ezra E.W. Cohen, Jason Chesney, Anthony Kong, Jonathan D. Cheng, Nicolas Mach

المصدر: Clinical Cancer Research, Vol. 26, No 19 (2020) pp. 5153-5161

مصطلحات موضوعية: Adult, Male, Oncology, Cancer Research, medicine.medical_specialty, Drug-Related Side Effects and Adverse Reactions, medicine.medical_treatment, Herpesvirus 1, Human, Pembrolizumab, Antibodies, Monoclonal, Humanized, 03 medical and health sciences, 0302 clinical medicine, Refractory, Internal medicine, Multicenter trial, medicine, Clinical endpoint, Humans, 030212 general & internal medicine, Neoplasm Metastasis, Adverse effect, Aged, ddc:616, Oncolytic Virotherapy, Biological Products, Chemotherapy, Squamous Cell Carcinoma of Head and Neck, business.industry, Middle Aged, medicine.disease, Combined Modality Therapy, Head and neck squamous-cell carcinoma, Progression-Free Survival, 030220 oncology & carcinogenesis, Female, Immunotherapy, Neoplasm Recurrence, Local, Talimogene laherparepvec, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e68d707fa9e943a6b37439bfbf54a5aTest
https://doi.org/10.1158/1078-0432.ccr-20-1170Test

5

The Genomic Landscape of Merkel Cell Carcinoma and Clinicogenomic Biomarkers of Response to Immune Checkpoint Inhibitor Therapy

المؤلفون: Michael J. Schell, Nikhil I. Khushalani, Howard L. McLeod, Vincent A. Miller, Kenneth Y. Tsai, Andrew S. Brohl, Jeffery S. Russell, Zeynep Eroglu, Jane L. Messina, Vernon K. Sondak, Todd C. Knepper, Ethan Sokol, Lee A. Albacker, Meagan Montesion, Garrett M. Frampton, James A. DeCaprio

المصدر: Clinical Cancer Research. 25:5961-5971

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Cancer Research, Skin Neoplasms, Immune checkpoint inhibitors, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Merkel cell polyomavirus, Genomics, Disease, Biology, B7-H1 Antigen, Article, 03 medical and health sciences, Antineoplastic Agents, Immunological, 0302 clinical medicine, Biomarkers, Tumor, medicine, Ultraviolet light, Humans, Aged, Aged, 80 and over, Merkel cell carcinoma, High-Throughput Nucleotide Sequencing, Immunotherapy, Middle Aged, medicine.disease, biology.organism_classification, Carcinoma, Merkel Cell, Survival Rate, genomic DNA, Treatment Outcome, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Mutation, Cancer research, Female

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60719333bb5486fadc38b774e91d057eTest
https://doi.org/10.1158/1078-0432.ccr-18-4159Test

6

Nivolumab in Patients with Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck: Efficacy and Safety in CheckMate 141 by Prior Cetuximab Use

المؤلفون: Jeffery S. Russell, Shanmugasundaram Ramkumar, Everett E. Vokes, Robert L. Ferris, Makoto Tahara, Maura L. Gillison, Lisa Licitra, Mark Lynch, Robert I. Haddad, Joël Guigay, Caroline Even, Nabil F. Saba, Kevin J. Harrington, Fernando Concha-Benavente, Jérôme Fayette, Li Li, Peter Brossart, George R. Blumenschein, A. Dimitrios Colevas

المصدر: Clin Cancer Res

مصطلحات موضوعية: Adult, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Cetuximab, Article, law.invention, 03 medical and health sciences, Antineoplastic Agents, Immunological, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, Clinical endpoint, medicine, Humans, Neoplasm Metastasis, Survival rate, Aged, Aged, 80 and over, Chemotherapy, Squamous Cell Carcinoma of Head and Neck, business.industry, Immunotherapy, Middle Aged, ErbB Receptors, Survival Rate, Clinical trial, Nivolumab, 030104 developmental biology, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Neoplasm Recurrence, Local, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a754089cc56f4bc972d5ecdf0accbd84Test
https://doi.org/10.1158/1078-0432.ccr-18-3944Test

7

A Variant of a Killer Cell Immunoglobulin-like Receptor Is Associated with Resistance to PD-1 Blockade in Lung Cancer

المصدر: Clinical Cancer Research. 25:3026-3034

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Oncology, Receptors, KIR3DS1, Cancer Research, medicine.medical_specialty, Lung Neoplasms, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Killer-cell immunoglobulin-like receptor, 03 medical and health sciences, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Internal medicine, medicine, Humans, Lung cancer, Aged, Aged, 80 and over, biology, business.industry, Genetic Variation, Immunotherapy, Middle Aged, medicine.disease, Immune checkpoint, Blockade, Treatment Outcome, 030104 developmental biology, Cytokine, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, biology.protein, Female, Nivolumab, Antibody, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b82d01d1a303de87b59f7533b7d2a1Test
https://doi.org/10.1158/1078-0432.ccr-18-3041Test

8

Immunotherapy Targeting HPV16/18 Generates Potent Immune Responses in HPV-Associated Head and Neck Cancer

المصدر: Clinical Cancer Research. 25:110-124

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Cancer Research, Drug-Related Side Effects and Adverse Reactions, Papillomavirus E7 Proteins, medicine.medical_treatment, Programmed Cell Death 1 Receptor, CD8-Positive T-Lymphocytes, Article, Interferon-gamma, 03 medical and health sciences, 0302 clinical medicine, Immune system, Antigen, medicine, Humans, Papillomavirus Vaccines, Antigens, Viral, Tumor, Aged, Human papillomavirus 16, Human papillomavirus 18, biology, business.industry, Immunogenicity, ELISPOT, Papillomavirus Infections, Cancer, FOXP3, Oncogene Proteins, Viral, Immunotherapy, Middle Aged, medicine.disease, Immunity, Innate, DNA-Binding Proteins, Repressor Proteins, 030104 developmental biology, Oncology, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Leukocytes, Mononuclear, biology.protein, Cancer research, Female, Antibody, business, T-Lymphocytes, Cytotoxic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185d078362ea6dfb406f8870236a7ad7Test
https://doi.org/10.1158/1078-0432.ccr-18-1763Test

9

PD-L2 Expression in Human Tumors: Relevance to Anti-PD-1 Therapy in Cancer

المؤلفون: Ni Yu, Masahisa Handa, Laura Q.M. Chow, Terrill K. McClanahan, Jared Lunceford, Joanne E. Tomassini, Christina Moon, Jonathan D. Cheng, Christopher E Gibson, Jennifer H. Yearley, Erin Murphy, Tanguy Y. Seiwert, Jonathan Juco

المصدر: Clinical Cancer Research. 23:3158-3167

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Stromal cell, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Pembrolizumab, Antibodies, Monoclonal, Humanized, Disease-Free Survival, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Carcinoma, medicine, Humans, Aged, Aged, 80 and over, Squamous Cell Carcinoma of Head and Neck, business.industry, Cancer, Immunotherapy, Middle Aged, Programmed Cell Death 1 Ligand 2 Protein, medicine.disease, Head and neck squamous-cell carcinoma, Blockade, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Immunology, Monoclonal, Carcinoma, Squamous Cell, Female, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa02a3b32e295f38058618a53480d54dTest
https://doi.org/10.1158/1078-0432.ccr-16-1761Test

10

Dynamic Changes in PD-L1 Expression and Immune Infiltrates Early During Treatment Predict Response to PD-1 Blockade in Melanoma

المؤلفون: Jason Madore, Ricardo E. Vilain, Serigne Lo, Alexander Guminski, Hojabr Kakavand, Valerie Jakrot, Benjamin Y. Kong, Adam Cooper, Richard F. Kefford, Elizabeth Liniker, Julie Howle, Georgina V. Long, John F. Thompson, Richard A. Scolyer, Robyn P. M. Saw, Alexander M. Menzies, James S. Wilmott, Matteo S. Carlino

المصدر: Clinical Cancer Research. 23:5024-5033

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Biopsy, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Kaplan-Meier Estimate, Pembrolizumab, CD8-Positive T-Lymphocytes, Antibodies, Monoclonal, Humanized, B7-H1 Antigen, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, 0302 clinical medicine, Immune system, Internal medicine, Biomarkers, Tumor, medicine, Humans, Melanoma, Aged, medicine.diagnostic_test, business.industry, Antibodies, Monoclonal, Cancer, Immunotherapy, Middle Aged, medicine.disease, Gene Expression Regulation, Neoplastic, Nivolumab, 030104 developmental biology, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Immunology, Female, business, CD8

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b869ec5aaea8fb7a2d4346207a799510Test
https://doi.org/10.1158/1078-0432.ccr-16-0698Test

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