دورية أكاديمية
Comparison of glomerular filtration rate estimating formulas among Japanese adults without kidney disease
| العنوان: | Comparison of glomerular filtration rate estimating formulas among Japanese adults without kidney disease |
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| المؤلفون: | Fujii, R., Pattaro, C., Tsuboi, Y., Ishihara, Y., Melotti, R., Yamada, H., Ando, Y., Ishikawa, H., Ohashi, K., Hashimoto, S., Hamajima, N., Barbieri, G., Ghasemi-Semeskandeh, D., Suzuki, K. |
| المصدر: | Clinical Biochemistry |
| سنة النشر: | 2023 |
| المجموعة: | Leiden Repository (Leiden University) |
| مصطلحات موضوعية: | estimated glomerular filtration rate (eGFR), Chronic kidney disease (CKD), Epidemiology, Kidney function |
| الوصف: | Background Previous studies have proposed different formulas of estimating glomerular filtration rate (eGFR) among clinical patients. The comprehensive comparison of eGFR formulas is not well established in a Japanese population. We compared eGFR values and chronic kidney disease (CKD) classification of nine different eGFR in a Japanese general population sample. Methods We analyzed 469 Japanese community-dwelling adults (184 men) without any self-reported kidney disease. GFR estimated using the 4- and 6-parameter Modification of Diet in Renal Disease (MDRD) formulas (MDRD4 and MDRD6); the CKD-EPI formulas based on creatinine with (CKD-EPI-2009) and without race coefficient (CKD-EPI-2021), on cystatin C (CKD-EPI-Cys), on both (CKD-EPI-CreCys); the Japanese creatinine-based formula (JPN-Cre), cystatin C-based formula (JPN-Cys), and modified CKD-EPI formula (JPN-CKD-EPI). CKD stages were defined by KDIGO guidelines (eGFR < 60 ml/min/1.73 m 2 ). Results eGFR JPN-Cre (mean = 71.2; SD = 14.3) were much lower than eGFR CKD- EPI -2021 (mean = 94.2; SD = 12.7), while eGFR JPN-Cys (mean = 102.8; SD = 24.2) was comparable to the MDRD and CKD-EPI formulas. The difference between eGFR CKD- EPI -2021 and eGFR JPN-Cre showed a V-shaped distribution across eGFR levels, indicating complex errors between these formulas. We observed very low agreement in CKD classification between eGFR JPN-Cre and the eGFR CKD- EPI -2021 (kappa = 0.13; 95% confidence interval: 0.06, 0.23). Conclusions JPN-Cre was substantially different from the CKD-EPI formula without race term (CKD-EPI-2021), which means that it is impossible to recalibrate those with a simple coefficient. Although a comparison with measured GFR should be necessary, choice of the estimation method needs caution in clinical decision-making and academic research. ; Horizon 2020 (H2020) |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://www.sciencedirect.com/science/article/pii/S0009912022002351?via%3DihubTest; lumc-id: 184494892; https://hdl.handle.net/1887/3666026Test |
| DOI: | 10.1016/j.clinbiochem.2022.10.011 |
| الإتاحة: | https://doi.org/10.1016/j.clinbiochem.2022.10.011Test https://hdl.handle.net/1887/3666026Test https://www.sciencedirect.com/science/article/pii/S0009912022002351?via%3DihubTest |
| رقم الانضمام: | edsbas.7CD811BF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.clinbiochem.2022.10.011 |
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