Manufacturing‐dependent change in biological activity of the TLR4 agonist GSK1795091 and implications for lipid A analog development
| العنوان: | Manufacturing‐dependent change in biological activity of the |
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| المؤلفون: | Neeltje Steeghs, Aaron R. Hansen, Glenn J. Hanna, Elena Garralda, Haeseong Park, James Strauss, Michael Adam, Gossett Campbell, Jennifer Carver, Rachael Easton, Katherine Mays, Peter Skrdla, Herbert Struemper, Michael L. Washburn, Christopher Matheny, Sarina A. Piha‐Paul |
| المساهمون: | Institut Català de la Salut, [Steeghs N] Netherlands Cancer Institute, Amsterdam, The Netherlands. [Hansen AR] Princess Margaret Cancer Centre, Toronto, Ontario, Canada. [Hanna GJ] Northwest Medical Specialists, Tacoma, Washington State, USA. Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [Garralda E] Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Park H] Washington University, St Louis, Missouri, USA. [Strauss J] Mary Crowley Cancer Research Center, Dallas, Texas, USA, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Anticossos monoclonals - Ús terapèutic, Càncer - Tractament, General Neuroscience, Antibodies, Monoclonal, Medicaments antineoplàstics - Ús terapèutic, acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antineoplásicos [COMPUESTOS QUÍMICOS Y DROGAS], Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores], Antineoplastic Agents, General Medicine, Other subheadings::Other subheadings::/drug therapy [Other subheadings], General Biochemistry, Genetics and Molecular Biology, Toll-Like Receptor 4, Neoplasms [DISEASES], neoplasias [ENFERMEDADES], Lipid A, Neoplasms, Antineoplastic Combined Chemotherapy Protocols, Humans, Cytokines, Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents [CHEMICALS AND DRUGS], General Pharmacology, Toxicology and Pharmaceutics, Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Antibodies, Monoclonal [CHEMICALS AND DRUGS], aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::anticuerpos monoclonales [COMPUESTOS QUÍMICOS Y DROGAS] |
| الوصف: | Biological activity; Solid tumors Actividad biológica; Tumores sólidos Activitat biològica; Tumors sòlids A phase I trial (NCT03447314; 204686) evaluated the safety and efficacy of GSK1795091, a Toll-like receptor 4 (TLR4) agonist, in combination with immunotherapy (GSK3174998 [anti-OX40 monoclonal antibody], GSK3359609 [anti-ICOS monoclonal antibody], or pembrolizumab) in patients with solid tumors. The primary endpoint was safety; other endpoints included efficacy, pharmacokinetics, and pharmacodynamics (PD). Manufacturing of GSK1795091 formulation was modified during the trial to streamline production and administration, resulting in reduced PD (cytokine) activity. Fifty-four patients received GSK1795091 with a combination partner; 32 received only the modified GSK1795091 formulation, 15 received only the original formulation, and seven switched mid-study from the original to the modified formulation. Despite the modified formulation demonstrating higher systemic GSK1795091 exposure compared with the original formulation, the transient, dose-dependent elevations in cytokine and chemokine concentrations were no longer observed (e.g., IP-10, IL10, IL1-RA). Most patients (51/54; 94%) experienced ≥1 treatment-emergent adverse event (TEAE) during the study. Safety profiles were similar between formulations, but a higher incidence of TEAEs associated with immune responses (chills, fatigue, pyrexia, nausea, and vomiting) were observed with the original formulation. No conclusions can be made regarding GSK1795091 anti-tumor activity due to the limited data collected. Manufacturing changes were hypothesized to have caused the change in biological activity in this study. Structural characterization revealed GSK1795091 aggregate size in the modified formulation to be twice that in the original formulation, suggesting a negative correlation between GSK1795091 aggregate size and PD activity. This may have important clinical implications for future development of structurally similar compounds. This study was funded by GlaxoSmithKline (204686; NCT03447314). |
| وصف الملف: | application/pdf |
| تدمد: | 1752-8062 1752-8054 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52a2c776e6853dfc712d9d3e7b04e11Test https://doi.org/10.1111/cts.13387Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d52a2c776e6853dfc712d9d3e7b04e11 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17528062 17528054 |
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